“Current dogma suggests combining geroprotectors with concurrent exercise blunts hallmarks of exercise that are associated with healthy longevity. Frequent (daily) dosing of leading geroprotectors blunts clinically relevant improvements to cardiorespiratory fitness, muscle size/strength/power, and insulin sensitivity. Along the aging continuum, identifying an appropriate age to begin intervening with combined approaches represents an opportunity to suppress the age-related decline in systemic health. Finally, manipulating dose or frequency of dosing may provide the opportunity to capitalize on the benefits of both regular exercise and geroprotectors to enhance healthy longevity to new heights.”
@Neo I was interested in the mention of acarbose as a mtorc2 activator…maybe to offset any mTORC2 deactivation from rapa. I’m going to add acarbose.
As far as exercise goes, I don’t worry about losing some of the benefits of exercising. I exercise because I like it. If I start to SEE problems such losing muscle mass, then I’ll adjust.
The one exception is metformin. I am going to take less of it. It just makes my cardio exercise harder…less enjoyable (this was mentioned in the paper as well). I’m going to take it only on the 3 days around my rapa dose which I am now only taking 1x / 14 days. This won’t interfere with my workouts or back to the drawing board.
