Learning about drug metabolism, P450 system is used to detoxify toxic substances in the liver, so I wondered if grapefruit are harmful on its own, and there is an association, but it could be because it affects drug metabolism, or other residual confounding.
When compared with non-consumers, frequent consumers of red wine, tea, peppers, blueberries and strawberries were at reduced risk of all-cause mortality (P<0·05), with the strongest associations observed for red wine and tea; multivariable-adjusted hazard ratios 0·60 (95 % CI 0·49, 0·74) and 0·73 (95 % CI 0·65, 0·83), respectively. Conversely, frequent grapefruit consumers were at increased risk of all-cause mortality, compared with their non-grapefruit consuming counterparts (P<0·05).
Considering threads like this:
- Rapamycin and Grapefruit Juice
- Grapefruit interaction with longevity meds?
- Grapefruit Extract vs Grapefruit Juice for Increased BioAvailability?
and that Brian Kennedy has wondered that it could increase side effects with rapamycin use, compared with equivalent dose without it, might be important to consider or research further.