'Good Energy'-New Book by Casey Means -Metabolic Health, Mitochondria and CGMs

Came across a couple of articles that led me to this.

Then found her website and watched the Andrew Huberman podcast/interview which was good but lengthy (almost 3 hours).

https://www.caseymeans.com/

@AlexKChen has her on his list of Memorable People and has mentioned her in other threads.
https://www.rapamycin.news/t/complete-list-of-memorable-high-openness-people-communities-focused-on-slowing-rate-of-aging/4722?u=ng0rge

Here’s the Amazon link to her book. Haven’t read it yet but I’ll look at the eBook.

https://www.amazon.com/Good-Energy-Surprising-Connection-Metabolism-ebook/dp/B0CFQ6KPDC

She’s the co-founder of Levels Health.

https://www.levelshealth.com/

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Her brother Calley is on the team with the good guys too. He does a lot of media stuff to get the message across.

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A central issue for Casey Means is mitochondrial function/health. Here is a short, very important Peter Attia clip on how to measure/test mitochondrial function. These are the type of tests (along with the SapereX test for senescent cells) that will really move the science forward.
The part where Attia describes the test runs from the 5 minute mark til the 10 minute mark.

https://youtu.be/7-gUBEOH1Ls?si=uooc0bYCH52PPVJM&t=300

Here’s also a good Reddit thread about the same thing.

https://www.reddit.com/r/PeterAttia/comments/197cjci/measuring_mitochondrial_function/

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Thx. It’s easy, but a bit cumbersome to do those tests today with finger pricks.

What might turn out to be a game changer is when we get Continous Lactose Monitors (CLMs) along the same lines as CGMs:

I agree and look forward to seeing them. Just did some searching and it looks like SuperSapiens is shutting down. Casey Means company Levels is a competitor that focuses on the health enthusiast rather than the athlete for glucose monitoring. Abbott just got FDA approval for over-the-counter sales of it’s Lingo CGM, however it still says:
“In the future, we could see biowearables with even more offerings. Glucose is just one of several important biomarkers that play a role in health and wellness. Don’t be surprised if you eventually see biowearables that can measure and interpret your body’s levels of ketones, lactate and more.”
So still no lactate sensors on the market (that I could find). I looked for updates on the IDRO device…nothing. Same for the PKvitality K’Watch Athlete.
I wonder if the Abbott Lingo will be capable of reporting both glucose and lactate? (in the future). This Forbes article seems to indicate that.

https://www.forbes.com/sites/brucejapsen/2024/06/10/abbott-wins-fda-approval-for-two-over-the-counter-diabetes-trackers/

It says - “The approvals come as Abbott, which already has a top-selling continuous glucose monitor for diabetes management known as Libre that generates more than $5 billion in sales annually, is developing a new line of biowearables including Lingo and Rio that track glucose levels, ketones and lactate.”

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What is Levels business model now that CGMs are available OTC?

They aren’t on the market in the US yet but should show up anytime now, both the Dexcom Stelo and Abbott’s Lingo and Libre Rio.
The business model, like many showing up online, is personalized health counseling (with blood testing) through an App subscription ($200/yr), so recommendations based on your individual test results (CGM and blood). See this page -
https://app.levelshealth.com/us/signup?softwareOnly=true
The blood tests that they recommend (optional if you want to do your own) are here (with very good analysis of their importance).
https://www.levelshealth.com/blog/the-ultimate-guide-to-understanding-your-cholesterol-panel-and-metabolic-blood-tests

Another very similar service is Zoe.com (also using CGMs) which offers both Membership/subscription to an App ($349/yr) and testing. The testing here:

“Testing: The total cost of the test kit is $294.00 or can be paid in six monthly installments of $49 each. This includes:
Gut microbiome test
Blood fat test
Standardised test meals - cookies!
Real-time blood sugar sensor (CGM) - if opted into our scientific study
Gut health report
Personalized insights report”
https://zoe.com/
Both companies are of course collecting data and then using that insight to improve their recommendations to subscribers.
Another one with more extensive testing (and supplements!) is Zest.science (already subject of another thread.)
https://www.rapamycin.news/t/functional-age-an-approach-to-measuring-this-new-app/8300?u=ng0rge

If you just want to hear Casey Means’ insight on CGMs (useful) go to the Huberman podcast above and listen to the segment from 2:19:30 - 2:33. (By the way, she says that the Abbott Lingo will be separate sensors for lactate and glucose and ketones.)

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After watching this, and hearing Attia describe Metformin as a mitochondrial poison and that he wouldn’t prescribe it, I watched the Kaerberlein Podcast with Brandon Berry on mitochondria. At the 1:12:00 mark Brandon says yes, metformin inhibits mitochondria but the cell responds by making more, new mitochondria and the upshot is an improvement in mitochondrial function. So, first…metformin-bad! get off it…next, metformin-good! get back on it.

https://www.youtube.com/watch?v=li8w4YZwpDo

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