It’s not correlated with blood epigenetic stuff
Sialic acid supplements…
https://www.tandfonline.com/doi/full/10.1080/10408398.2022.2072270
This may be the only feedback loop against nut binges (for now)
This is also a strong feedback loop for 17ae…
There have been glycanage age reductions of 37 years (with someone who has a very special-ish diet).
It’s not the best indication of aging, but it is something…
===
N-acetyl-D-mannosamine (ManNAc, sialic acid precursor) is another way to supplement. But CR seems to increase sialytion (gah waiting for my SLG)
https://www.sciencedirect.com/science/article/pii/S2214426921000719
Compared with IgG from control chow-fed mice, IgG from HFD-fed mice was hyposialylated, and it raised BP when transferred to recipients lacking IgG; the hypertensive response was absent if recipients were FcγRIIB-deficient. Neuraminidase-treated IgG lacking the Fc glycan terminal sialic acid also raised BP. In cultured endothelial cells, via FcγRIIB, IgG from HFD-fed mice and neuraminidase-treated IgG inhibited vascular endothelial growth factor activation of endothelial NO synthase by altering endothelial NO synthase phosphorylation. In humans, obesity was associated with lower IgG sialylation, and systolic BP was inversely related to IgG sialylation. Mice deficient in FcγRIIB in endothelium were protected from obesity-induced hypertension. Furthermore, in HFD-fed mice, ManNAc normalized IgG sialylation and prevented obesity-induced hypertension.
Nut binges might cause hyposialyation…
