Hyperglycosylation is a metabolic driver of Alzheimer’s disease
https://www.nature.com/articles/s42255-026-01538-4
Pop sci article:
Study links joint pain supplement to accelerating dementia
In addition, researchers found that taking glucosamine was associated with a 25% increase in mortality risk, or the likelihood of death within a specified time frame, among ADRD patients. For the MCI group, there was no such impact, suggesting the impact of glucosamine may be greater in patients with established dementia.
As the headline makes clear, glucosamine accelerates , not causes dementia - even assuming this effect is real in the first place (the study is only associative). The question becomes how tissue that is vulnerable or in prodromal (non symptomatic) phase reacts to long term glucosamine supplementation (assuming this effect is real). Before any official diagnosis or MCI. Everyone has their own medical situation and specific vulnerabilities. This is a possible signal, not a definitive causal relationship. That said, it always pays to regularly interrogate all your drugs, supplements and interventions to make sure it still has a place in your stack as knowledge accumulates. Ask yourself for example why are you supplementing with glucosamine and if any potential risks are worth the purported benefits.
The headline isn’t clear. Accelerates from what point? That unqualified statement isn’t consistent with the contents of the paper.