I found out some time ago that https://gethealthspan.com has a test to measure Sirolimus levels in the blood. It costs me $25. The more interesting thing about it is that they analyze your results to help you determine if the level in your blood is therapeutic. I found their classification fascinating. I don’t know how they came up with them. Here they are.
For peak level of Sirolimus
Testing should occur after 2-4 hours. Here are the possible values:
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less than 10 ng/ml: Insufficient dosage
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10-20: optimal dosage
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more than 20: higher than necessary, might lead to side effects
For through levels of Sirolimus
Testing should occur 24-48 hours before your next dose. Possible values:
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less than 1 ng/ml: optimal value
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more than 1: you might want to wait longer before your next dose
For mid-cycle levels of Sirolimus
This one I was not famillair with. The idea is to measure how fast the drug is being cleared from your system. Your peak value might be fine, but if you clear the drug too fast, you might miss some benefits of the drug. This is scheduled 72 hours after your initial dosage
Possible values:
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less than 3 ng/ml: the drug has cleared from your system too fast
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more than 3: optimal value
So it seems that the protocol above makes a good compromise between a relatively high peak (10-20 ng/ml after 4 hours), and moderate AUC (3+ ng/ml after 72 hours).
Using these guidelines, I found out that I clear Sirolimus much faster than I expected: I spent several years at 3 mg per week or more, but to obtain the numbers in the therapeutic ranges outlined above, I had to go up to 10 mg per week.
This does highlight the fact that talking about dosage in mg can be misleading, and for people that have access to it, talking about ng/ml might be more accurate. Maybe the guidelines could serve as a protocol for future studies.
I would be curious to know what people think of this protocol described above, and where they think these numbers they in the protocol came from.
I’ve attached my results as a PDF
Healthspan _ Patient Portal.pdf (62.6 KB)