Genistein extends maximum lifespan and alleviates frailty in aging mice

Genistein extends median, mean, and maximum lifespan in C57BL/6J mice when started at 16 months of age.

9.3% increase in median lifespan
9.2% increase in maximum lifespan
10.0% in mean lifespan


“Genistein treatment decreased the severity of multiple age-dependent phenotypes, including poor coat condition, fur color loss, and tail stiffening.”

“Genistein-fed mice manifested delayed loss of body weight and visible signs of aging.”

“Genistein treatment for 8 months reduced the levels of a large proportion of pro-inflammatory cytokines (IL-1α, IL-2, IL-6, TNF-α, CCL2, CCL5, CXCL1, and CXCL5) in aged animals.”


Interesting… But wish we had access to the full paper. How many mice in the trial…?

The full text is free access. You just have to scroll down. 29 in control group. 24 in genistein group.

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Male mice

y’know I remember my old AOE2 clan ex-leader complaining about soy reducing masculinity/testosterone in males. IMO this is only a good thing

2.7.2. Kinetic Study of the Inhibitory Effects on the Formation of AGEs by Genistein

Since genistein was determined as the most effective natto isoflavone in trapping MGO, we further selected genistein to evaluate its kinetics of AGEs inhibition. BSA (30 mg/mL) was incubated with MGO (60 mM) in the presence or absence of genistein (200 μg/mL) in a phosphate buffer solution (0.05 mol/L PH 7.4). The reaction mixture was collected at different time points (240, 480, 720, 960, 1200, and 1440 min). Fluorescence at an excitation/emission wavelength of 370/450 nm, which is characteristic of AGEs, was used to measure AGEs levels.