Gene Therapy Reverses Age-Related Hearing Loss

Summary: Researchers successfully demonstrated the efficacy of adeno-associated virus (AAV) vectors in reversing genetic hearing loss in aged animal models. The scientists developed a mature mouse model with a mutation similar to the human TMPRSS3 gene defect, which typically results in progressive hearing loss.

Upon injecting these mice with an AAV carrying a healthy TMPRSS3 gene, a notable restoration of hearing was observed. This advancement suggests the potential of gene therapies to treat genetic hearing loss, even in advanced age.

Original Research: Open access.
Rescue of auditory function by a single administration of AAV-TMPRSS3 gene therapy in aged mice of human recessive deafness DFNB8” by Zheng Yi Chen. Molecular Therapy