I know that this was originally posted in January 2023, but I don’t remember seeing much of it around.
I am myself not that much of a fan of using the Yamanaka factors.
They used old mice at 124 weeks and found that the controls lived (median) to ~133 weeks and the treated to 142.5
Which is 109% increase of the lifespan since 124 weeks, but otherwise a 7% increase.
To be honest one reason why I think this has not got a lot of publicity is that Rapamycin has a greater extension of lifespan although I don’t know about the specific situation of taking progeroid mice and intervening at a really late stage.
My view on the reprogramming is that its main effects lie in SOX2 (or some other gene) encouraging autophagy.
Also " We isolated DNA from heart and liver tissue from control and TRE-OSK treated mice at time of death and found that the Lifespan Uber Clock (LUC) for both liver and heart trended towards reduced epigenetic age "
Which given that the mice had died to some extent undermines the idea of the aging clock as measuring mortality.
However, I thought people would be interested to see this if they haven’t already done so.