From geroscience to precision geromedicine: Understanding and managing aging

#1

https://www.cell.com/cell/fulltext/S0092-8674(25)00284-3

Summary

Major progress has been made in elucidating the molecular, cellular, and supracellular mechanisms underlying aging. This has spurred the birth of geroscience, which aims to identify actionable hallmarks of aging. Aging can be viewed as a process that is promoted by overactivation of gerogenes, i.e., genes and molecular pathways that favor biological aging, and alternatively slowed down by gerosuppressors, much as cancers are caused by the activation of oncogenes and prevented by tumor suppressors. Such gerogenes and gerosuppressors are often associated with age-related diseases in human population studies but also offer targets for modeling age-related diseases in animal models and treating or preventing such diseases in humans. Gerogenes and gerosuppressors interact with environmental, behavioral, and psychological risk factors to determine the heterogeneous trajectory of biological aging and disease manifestation. New molecular profiling technologies enable the characterization of gerogenic and gerosuppressive pathways, which serve as biomarkers of aging, hence inaugurating the era of precision geromedicine. It is anticipated that, pending results from randomized clinical trials and regulatory approval, gerotherapeutics will be tailored to each person based on their genetic profile, high-dimensional omics-based biomarkers of aging, clinical and digital biomarkers of aging, psychosocial profile, and past or present exposures.

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#2

Following looking at that paper I decided to look for the GRAS list

https://www.hfpappexternal.fda.gov/scripts/fdcc/index.cfm?set=SCOGS&sort=Sortsubstance&order=ASC&startrow=351&type=basic&search=

I found it interesting that Magnesium Citrate was not on the list although it has an E number (345)

This is relevant because I am going through the regulatory process of asking the nutrition committee in the UK to allow me to sell citrate salts with the claim of accelerated wound healing.

#3

Here is a link to the UK Nutrition and Health Claims Committee

Its an interesting regulatory issue. As I read it four applications have been made since the UK left the EU (as the rules are the same across the EU) and all have been rejected.

It will be interesting to see what they might agree could be said about citrates speeding up wound healing. I have solid evidence with photos as far as my weekly venepuncture goes, but I also have anecdotal evidence from other people.