Preliminary results (low N) show decreased epigenetic age, and increased muscle to fat ratio.
My main concern is the plasmids get into the nucleus and it’s unclear if they will contribute to nuclear crowding (or if over the long run some of the DNA won’t decay and could get integrated into the nucleus via LINE1 retrotransposons).
It’s a very quick (10-20 second) and relatively painless injection.
It apparently increases circulating follistatin levels to around 22 ng/mL – around the level of a teenager, but far less than a pregnant woman or a newborn, which is around 55-60.
And while follistatin does inhibit GDF11 due to the similarity between GDF11 and myostatin (aka GDF8), my best guess is that this level is probably not high enough to significantly reduce GDF11 levels. And you can always order GDF11 from CanLab, or join Steve Perry’s study, if you’re worried about that.
It’s temporary (lasts 18 months), and it even has a built-in kill switch so you can instantly reverse it with tetracycline or doxycycline.
They reported around 3.5 pounds of muscle mass gain and 3.5 pounds of fat loss for the average participant so far.
It also requires monthly DEXA scans and blood tests for a few months before and after participation.
If interested in being part of January’s cohort, email email@example.com and tell them I sent you.
If you end up participating, be aware that although the resort they suggest (Las Verandas https://www.lasverandasroatan.com) is quite beautiful, it has no amenities besides a small beach and a few pools (no fitness room and no place to buy goods, and the nearest supermarket really requires a taxi to reach), and I personally found most of the rest of the island a bit on the sketchy side.
So unless you enjoy just chilling by the pool (and have a significant other to hang out with), I recommend making your trip as short as you can – I ended up wishing I’d just flown in the day before and left the day after.
Elevated circulating follistatin associates with an increased risk of type 2 diabetes
In human adipocytes, follistatin dose-dependently increases free fatty acid release. In genome-wide association study (GWAS), variation in the glucokinase regulatory protein gene (GCKR ) associates with plasma follistatin levels (n = 4239, Sweden; n = 885, UK, Italy and Sweden) and GCKR regulates follistatin secretion in hepatocytes in vitro. Our findings suggest that GCKR regulates follistatin secretion and that elevated circulating follistatin associates with an increased risk of T2D by inducing adipose tissue insulin resistance.
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