Wondering if anyone else has been testing out. I checked out usage with AI and it seemed positive, but pointed out there have been no long term trials:
Emerging Clinical Evidence in Humans
While robust human data are still limited, early clinical studies and pilot trials suggest that intermittent high-dose fisetin can indeed target senescent cells and lower inflammation in people.
Fisetin is a natural flavonoid (found in strawberries, apples, etc.) that has attracted attention as a senolytic – a compound capable of selectively eliminating senescent “zombie” cells. Unlike chronic daily supplements, fisetin is typically investigated in high-dose, intermittent cycles (e.g. ~20 mg/kg, roughly 1,400–1,800 mg/day in humans, for 2 consecutive days, repeated every 4–8 weeks). This dosing strategy aims to periodically clear senescent cells without continuous exposure. Senescent cells accumulate with age and secrete pro-inflammatory factors (the SASP, or senescence-associated secretory phenotype) that contribute to tissue dysfunction. By clearing these cells, senolytic treatments like fisetin could reduce inflammation and frailty and improve tissue function in aging. Below, we evaluate the evidence from animal models and emerging human studies for fisetin’s senolytic effects – focusing on outcomes in older adults – and compare fisetin to other geroprotective agents such as rapamycin and quercetin. We also discuss optimal dosing protocols (frequency, food effects, co-supplements) and highlight areas of expert consensus versus debate (e.g. results from the NIA Interventions Testing Program vs. Mayo Clinic studies).