Ferroptotic stress promotes hematopoietic stem cell aging through S1P-dependent epigenetic and lipid remodeling

#1

If someone can put here the full paper?

https://ashpublications.org/blood/article/doi/10.1182/blood.2026034204/570472/Ferroptotic-stress-promotes-hematopoietic-stem

Its crazy data here if true

1 Like
#2

And another lifespan extension through taking care of HSC. The picture is becoming quite clear. Of all the systems that decay with aging, HSC seems to draw a hard limit in mice.

#3

They used ABC294640, an unapproved Sphk2 inhibitor, and vitamin E was shown to block S1P-induced lipid peroxidation and cell death in young HSCs in vitro.