FDA Approved Insulin Inhibition Drug (Alpelisib) Extends Mouse Lifespan by 10%

From the University of Auckland:

The age-old quest for immortality has taken a step forward with the results of an Aotearoa New Zealand study just published in leading international journal Nature Ageing (see links at bottom of story).

The Waipapa Taumata Rau, University of Auckland trial demonstrates that long-term treatment of healthy mice from middle-age (one year) with a drug currently used to treat cancer can increase their lifespan by an average of ten percent to around three years.

In this study, mice were fed a control diet or the same diet with the addition of a drug called alpelisib. Not only did the mice fed the drug containing diet live longer, they showed some signs of being healthier in old age such as improved coordination and strength. However, the researchers are cautious about application to humans since the mice treated with the drug also had some negative markers of ageing like lower bone mass.

“Ageing is not only about lifespan but also about quality of life,” says research fellow Dr Chris Hedges. “Therefore, we were pleased to see this drug treatment not only increased longevity of the mice but they also showed many signs of healthier ageing. We are working now to understand how this happens.”

Principle investigator Associate Professor Troy Merry says: “We are not suggesting that anyone should go out and take this drug long-term to extend lifespan, as there are some side effects. However, this work identifies mechanisms crucial to ageing that will be of use in our long-term efforts to increase lifespan and health-span. It also suggests a number of possible ways in which shorter term treatments with this drug could be used to treat certain metabolic health conditions and we are following this up now.”

Professor Peter Shepherd says that alpelisib targets an enzyme called PI 3-kinase.

“We have been working on developing drugs to target PI 3-kinase for more than 20 years as evidence indicated they would be useful to treat cancers as many cancers have an excess activation of this pathway.

“Therefore, it’s great to see that these drugs might have uses in other areas and reveal novel mechanisms contributing to age-related diseases. It also shows the value of long-term investment in research is areas such as this.”

Side Note on Using Alpelisib

The drug was approved for use by the FDA in 2019. Given this, the price right now is still extremely high as there is no generic competition. See “list pricing” below for buying one month’s supply of the drug without insurance coverage for it:

The DrugPatent Database suggests that " Piqray will be eligible for patent challenges on May 24, 2023 . This date may extended up to six months if a pediatric exclusivity extension is applied"

Paper (Behind Paywall):

Dietary supplementation of clinically utilized PI3K p110α inhibitor extends the lifespan of male and female mice

https://www.nature.com/articles/s43587-022-00349-y

Related Reading:

PI3Kα inhibition reduces obesity in mice

Partial inhibition of PI3K is one of the best-validated and evolutionary conserved manipulations to extend longevity.

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The cost in the USA is;

Piqray(alpelisib)oral tablet

from $21,498.03 for 56 each

|Quantity|Per unit|Price
|
56 tablets 100mg each
(2 x 28 each)
$383.89 | $21,498.03

I do not see people rushing to purchase this compound for longevity use.

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Makes purchasing rapamycin seem like chump change … lol.

Thanks!!

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It makes Rapamycin look like a no-brainer.

Unfortunately, price does matter for something that must be taken regularly.

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