Following on from John Hemmings great data, I did a really simple track on my last rapa dose (14 mg every 2 weeks) and I was pretty surprised of the effect it had for 2-4 days.
Chart is below - but being in pre-diabetic range for fasting glucose was a larger effect than I was expecting.
What are other people’s experience with this and do they do anything to mitigate it, whether it be fasting or medication. Seems like ti would be worth doing something to mitigate it for those 2-4 days after dose.
Kind of makes sense to me now why Rapa + arcabose has a better effect than rapa alone given that would get rid of this potential downside.
Other background. I am a 52 yo male, very fit (V02max 59) and not carrying much fat or other signs of pre diabetes. I eat very limited fruit or sugar and small amounts of starch vegetables.
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What is the source of this? (Dexcom/Abbot/somethig elses) What I found (with a dose every 6 weeks) is quite a big growth and then a falling off (and a finishing HbA1c of about 4.7-4.8).
This seems to go up and down by days. That could happen if you are drinking alcohol on 4th November and 7th November or doing something else to bring down glucose (possibly a cycle ride or something) and then the results are reasonable. It does show quite a high initial peak. It looks like you took Rapamycin on 1st November, but it could have been 31st October.
I think the threshold for a glucose effect is actually quite low which gives a sort of binary result where the glucose goes higher for a while and then drops.
BTW I think the values are mmol/l rather than mmol/dL
Personally I am not worried if Rapamycin pushes my glucose high for a week as it does not last.
My most recent dose had some higher peaks which did cause some concern, but I have not worn a CGM for a while. I am planning my next dose for 8th Dec.
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Hi John,
Source is accusense pin prick meter - morning reading (same time) to get fasted glucose - which i think are as accurate or more so than CGM. (thanks for the units correction)
I will go CGM next time - but when I saw your data, I thought this was the quickest, simplest and most accurate way I could do it as well.
Rapa was on 31 Oct. I had one glass of wine with friends on the 7 Nov. Apart from that it was a low carb diet. Generally I am a non-drinker - but have a glass maybe once ever 3 months.
I agree about low threshold and it being binary. I looked at your results and I think my spikes are relatively similar despite taking 1/4 the effective dose.
Having blood glucose spikes is not great, clearly, so personally this makes me thing longer spacing between dosing is better. I have gone from 7mg/ week to 14 mg/ 2 weekly. But think I will probably go out to 3 weekly. Right now I am cycling off for 6 weeks, but when i go back on, I will do a CGM for 4 days before dose and record for 10 after and see what it looks like.
I know @RapAdmin has tried a number of glucose lowering meds - I assume that is to counter this effect. Be interested to know your thoughts on taking these meds just for the 4-5 days that you take rapa, if say you went to a 3 weekly cycle?
Appreciate the feedback.
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Because glucose varies so much i think a CGM will provide more actionable data.
maybe.
Fasted glucose when you wake up seems like a pretty good baseline point to measure though.
I’m more onto what type of action now in terms of mitigating the baseline glucose increases that rapa seems to cause.
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I think if you are going to pick a point daily to measure glucose that is probably the best practical point. However, there are both test result variations and variation over short timescales.
It is clear that Rapamycin increases baseline glucose whilst active I think this is hepatic insulin resistance to some extent. Hence the first question is whether to mitigate this.
I don’t try to mitigate it as at the end of my cycle HbA1c is <5.
However, I will do some more tracking with CGMs at various points in the cycle and could change my mind on that.
