Explainable Biological Age (uses Shapley values)

#1

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https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00189-7/fulltext

respective percentages of individuals in which they appear among the top 20 most important risk factors, are as follows: long-standing illness, disability, or infirmity (29 376 [97·92%] of 30 000); cystatin C (23 487 [78·29%] of 30 000); overall health rating (21 372 [71·24%] of 30 000); average total household income before tax (21 024 [70·08%] of 30 000); red-blood-cell distribution width (20 370 [67·90%] of 30 000); pack years of smoking (18 072 [60·24%] of 30 000); past tobacco smoking (17 646 [58·82%] of 30 000); sex-hormone-binding globulin (15 534 [51·78%] of 30 000); and lymphocyte percentage (15 462 [51·54%] of 30 000).

SHBG increases ACM??

#2

Thanks. This is the second viewing of cystatin-c as a critical biomarker. It makes me think the key is to let the body do its thing. It knows what to do. If we can stop wrecking it, everything will get better. In this case it’s kidney function. Don’t mess it up with high BP. NO, exercise, stress, hydration, sodium/potassium, nasal breathing (co2 tolerance), etc.

If kidney function is down, this has to be a focus.