They sell the NAD+ ( Nicotinamide Adenine Dinucleotide) injectable, needles for $350. Seems ripe for FDA cease and desist but thats another issue. Anyone have experience with this product? My wife has a few bad joints that this product may be of help. We are already keto, wear CGMs, fast, red light, PEMF. This might be a help.
I’ve been on rapa and the Johnson’esk kitchen sink for a few years, and doing ok.
It appears that NAD+ via IV is rapidly converted. I’m not convinced that IV application of NAD+ provides any better result than using a precursor like NR or NMN. I’m personally not interested in doing IV therapy that would be required for a lifetime to get a benefit.
I don’t see any studies on subcutaneous injection and I’m pretty sure? NAD+ orally has zero benefit due to the action of the digestive system.
A lifetime of taking an oral supplement is something I can tolerate.
A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+
In conclusion, this study was able to reveal for the first time some very useful, previously unknown, information about the fate of exogenous IV NAD+ in humans including, the overall safety and tolerability of an IV NAD+ infusion at a rate of 3 ÎĽmoles/min, the rapid sequestering of NAD+ from the plasma, the likely contribution of both NAD+ glycohydrolase and NAD+ pyrophosphate activity in the metabolism of NAD+ and the apparent efficient renal tubular reabsorption of NAM.
I’ve been taking NMN for NAD boosting. It helps with jet lag (I don’t get jetlagged when I take NMN) and an energy boost (placebo?). Due to its effects on jet lag, I know it is doing something. Whether it is going to improve my lifespan is another question. There are many other things that I feel are more useful. NMN is just useful enough that I haven’t dropped it yet.
@DeStrider Did you ever try niacin or nicotinamide (or NR) to see if you get the same effect? I have on occasion felt an energy boost after taking 500mg of niacin before a workout. I think the key was feeling low energy at first (for unknown reasons). I’ve never felt anything from nicotinamide (or NR, when I used to take it); maybe it’s a dosage thing.
I also take extra creatine on sleep deprived days for alertness. It does seem to greatly delay the onset of sleepiness without ruining the next sleep.
NAD+ is weird, the science tells us the cells cannot utilize NAD+ circulating out side the cells, that it has to be broken down into NMN and/or NR to before it can be absorbed by cells as part of the salvage pathway. Once the NMN or NR is absorbed into the cell it can then be converted back into NAD+ inside the cell.
A lot of “work” to get NMN and NR into your cells when you can just take NMN or NR on their own. There is plenty of clinical evidence that oral use of these 2 does increase telomerase and NAD+.
So injecting either subQ or via IV drip should not provide much of a direct benefit with respect to cellular levels of NAD+… yet I have several clients who swear by it and demand it on a regular basis as they claim it really boosts their energy levels.
Plus the subQ dose of 1.0mg per shot is significantly lower than the 2 hr IV drip protocol of 10.0+ mg . Which according to many, will increase inflammation as the NAD+ is broken down before it can be used by cells.
I don’t know if it’s placebo or if the “energy” is coming from a different pathway that is yet to be fully understood.
I guess I’ll have to try it and see if I feel what they feel.
I’ve had aprox 4 NAD subq shots now. 2 were at .50ml
Placebo or not, my workouts were fire on it.
@julianj1 I’ve heard that even compounding pharmacies have trouble making effective skin preparations because getting it right is hard to do… if that is true, I assume the same of NAD patches. Just a guess on my part.
I saw that but asked both ChatGPT and Grok and it seems to have a neutral or even slightly beneficial effects according to several studies. If I were to add it, I would probably take 300mg NR
When using any AI to search for reliable facts, always add this to your search prompt,
“use only clinical studies published in reputable journals, NO influencers, NO youtube, NO clinics”
In the attached PDF, you can see that the initial search seems to indicate that exogenous NAD+ has a benefit BUT when a guardrail is put in place and the AI is only allowed to use biological science as a source, the information changes significantly.
If you don’t you will get all the internet influencer OPINIONS. Which opinions, in general, are skewed by the revenue generated by those opinions. When spas and clinics are selling $300 to $500 NAD+ 2 hours IV’s for a product that costs pennies, you may find the established BIOLOGY of how NAD+ works is cast aside.
Exogenous NAD+ cannot not work as advertised, period, end of story.
Actually, I was wrong. It was Grok that said there wasn’t much of an increase in homocysteine when I specifically asked about 300 mg of NR.
ChatGPT, oddly enough, does say there’s a small increase in homocysteine at a dose of 300 mg of NR.
So while AI has come a long way in the last couple of months, we can still see it isn’t perfect since two apps are contradicting themselves. That being said, not using AI apps for these longevity topics would really be a tremendous disservice at this point given how far they’ve come.
Some NAD research group put up a few youtube videos some time back, sorry can’t find, said the expensive precursors, NMN, NM, worked but for the $$ plain niacinamide worked well too.
When paired with a CD38 knock out (the enzyme that depletes NAD) like some dose of apigenin AM/PM and / or a stronger yet still cheap compound 5Amino-mq (easily found oral and injjectable) can keep NAD in play.
A newer compound with single source pitching it is: 1-mna,
which when google ai compares to 5amino, it seems 1-mna has wider health benefits. All TBD.
My questionable kitchen sink protocol; apiginen about 750mg AM/PM, 1amino-mq 750mcg injected AM, Another pathway mitchondria boosting agent; SLU-PP-332 available oral and injected, injected at 200mcg AM.
I’m starting an experiment of ALSO injecting NAD at ramping up dosing to see if any benefit on top: 50mg, 100mg, 200mg with a week or so in between. TBD
At 72yo some age related justification for such experimentation, to me anyway. I have low hopes for soome noticable benefit. I am a near zero responder to these interventions. I could list a long list and some very expensive that I felt no benefit including decent amounts of klotho-1 / day.
The main nutrical/drug that I DO feel benefit is modifinil at 100mg M-F AM or 200mg early AM on some day where dangerous activity is involved like cross country driving. IMHO I strongly reco everyone have a stash of modifinil on hand as we age JUST for the dangerous activities we have to successfully navigate to reach this mithical 100+yo. Modifinil!!!
