I lost 5 lbs in 5 weeks taking Tirzepatide in relatively small doses, 2.5mg/wk. I stopped almost 2 weeks ago, but my appetite is still suppressed.
It’s a matter of semantics, but it doesn’t suppress appetite it suppresses stomach emptying.
This had such a significant effect on me because I use time-restricted feeding. I eat dinner between 5&6 PM; my next meal is ~18 hrs later. This gives plenty of time for the stomach to empty. The problem is that I am hungry when I eat my first meal of the day, so I eat a full meal. There are usually only 5-6 hrs between my first meal and supper. This is not enough time for my stomach to empty, so I have barely touched my evening meal.
The result is basically OMAD. I didn’t get enough calories in the first meal, so the weight drop was faster than expected.
BTW: I have had no side effects fromTirzepatide at these doses.
I was going to try Retrutide next, but I don’t need to.
“Glucagon-like peptide-1 (GLP-1) receptor agonists suppress appetite by delaying gastric emptying. GLP-1 receptor agonists, such as liraglutide and exenatide, have been shown to slow gastric emptying, which contributes to increased satiety and reduced food intake. This mechanism is part of their overall effect on appetite regulation and weight management.
The American College of Cardiology notes that GLP-1 receptor agonists delay gastric emptying, leading to increased satiety and reduced food intake.[1] Additionally, studies have demonstrated that GLP-1 receptor agonists inhibit gastric emptying and food intake in both animal models and humans.[2-4] This delay in gastric emptying is a significant factor in their ability to reduce postprandial glucose levels and promote weight loss.”
These meds suppress appetite via effects in the brain, and this is thought to be their primary mechanism of action. The quote you posted is incomplete and outdated.
I just happened to be re-reading the abstract from the GLP-1/sinoatrial node study, and noticed this quote: “neither cervical vagotomy, adrenergic blockers (alpha, beta, or combined alpha-beta blockade), ganglionic blockade (hexamethonium), nor inhibition of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels (ivabradine) abolished the marked chronotropic effect of GLP-1”
Ugh, I hope it wasn’t my idea about the ivabradine. Looks like diltiazem may be the only real hope here.
I also came across this study in dogs, where glucagon also increased heart rate and also wasn’t affected by beta-blockers but was prevented by verapamil:
Looks like non-dihydropyridine CCBs for the win (hopefully!)
I wonder what AI would have said about Mediator (benfluorex) before it was withdrawn😜! AI only repeats what information is out there, and poor with synthesizing new insights.
That’s where I disagree: for now they’re mostly useless and dangerous. Unfortunately. I pay for ChatGPT pro and Perplexity Pro and spend a lot of time testing them on medical questions: it’s bad. The average regular user here is smarter.
Do they provide references at the end of their answers? Dr. Oracle does, and they’ve always checked out (in agreement with the answer), at least so far for the questions I’ve asked (which admittedly are fairly straightforward questions).
There are some medical AI-specific sites that I would trust over my primary provider.
I have had several primary providers over the years, and I can’t say any of them were current on the latest studies or treatments. I would undoubtedly use AI as a second opinion. The insurance system constrains my primary providers, and AI doesn’t.
Two, I would suggest that you look at: One is a very reasonably paid subscription, and the other is free. They are both better than paid ChatGPT Pro (Which I pay for but do not use for medical advice)
Both of these sites provide references for everything they claim. They never give phony references. You can read the response and references and make your own decision.
Liner AI also provides references in their responses, although I have seen them answer things a certain way and the accompanying links don’t completely back up what the AI says, so I have to verify the sources they include to make sure.