Open Evidence…
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They provide references. I also have access to Vera Health, a paid AI solution for doctors only. (I’m not a doctor, but I know the team. If you’re a doctor and want access, you can join the waitlist here)
Yes, for simple questions, they’re good. And they’re better than most doctors. Because most doctors don’t even know or follow the guidelines… And yes, for a second opinion or to challenge your PCP they’re also very good, I agree with you @desertshores and @MichGuy12.
But when you go into something more complex, out of the ordinary, or more prospective, without a clear and definite answer, they can say random things, sometimes totally wrong.
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Unfortunately for Open Evidence, after a few questions you’re blocked and told “Unlimited question-asking on OpenEvidence is free for verified health care professionals (HCPs) and medical students. If you are an HCP or a medical student please verify your registration for continued access to free unlimited questions on OpenEvidence.” There’s no way to pay to bypass the gatekeeping. I asked a few “open” questions such as “For someone with hypertension and at risk of cognitive decline (family history + genes), are some antihypertensive drugs better than other? What should they use?” and it’s doing OK! You need to guide it a bit but it eventually suggests telmisartan + amlodipine to reach BP <130/80 mmHg.
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Very interesting Eric Topol’s interview of Lotte Bjerre Knudsen: The Scientist Who Drove GLP-1 Drugs For Obesity and Alzheimer’s
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Davin8r, what are your thoughts on the various laser treatments for face, neck and possibly arms related the possibility of a permanent change in skin pigmentation (or shading) of the areas treated? Are some types of treatments such as Fraxel laser more or less likely than other types of laser treatments to cause any permanent skin pigmentation changes?
Jay, I don’t do cosmetic dermatology procedures so I’m definitely not an expert on lasers. From personal experience, I’ve had fraxel probably 6 or 7 times over the past 14 years and have never had issues with hyperpigmentation. I’m sure it’s more common in darker skin types and in people with an existing pigmentation disorder such as melasma.
Oh cool I didn’t realize Eric Topol had a podcast. Now I have a bunch of new videos to look forward to hearing on my walks.
There are a lot of GLP1 receptors in the brain… why? part of another poorly (until recently) understood feedback loop that is gaining traction.
Stimulating these central amygdalar neurons curtail hedonic feeding, whereas targeted deletion of the receptor in this cell population specifically diminishes the anorectic efficacy of GLP1RAs for reward-driven intake. These findings reveal a dedicated neural circuit through which small molecule GLP1RAs modulate reward processing, suggesting broad therapeutic potential in conditions of dysregulated dopamine signaling including substance use disorder and binge eating.
A Brain Reward Circuit Inhibited By Next-Generation Weight Loss Drugs
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Here is some feedback on my heart rate data after taking semaglutide 3.5mg twice weekly for 4 weeks then switching to tirzapatide 2 mg weekly and 3mg /week for the last week.
Each dot is the average nightly HR on 1 week from my Oura ring 4.
There was a steady rise from 55 to 65, with a dip week 4 when I switched the kind of GLP-1RA, but then it’s coming back to normal and is now only 57. That’s good news!
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