EVs as a better delivery agent for mRNA vaccines

Programmable RNA Loading of Extracellular Vesicles with Toehold-Release Purification

Finally, we demonstrated encapsulation of mCherry mRNA, transfection, and improved translation using the EVLs compared to liposomes or LNPs in HEK293-H cells. We envision this as an important tool for the EV-mediated delivery of RNA therapeutics.

https://pubs.acs.org/doi/10.1021/jacs.3c13123