Accumulation of F-actin drives brain aging and limits healthspan in Drosophila . Nature Communications , 2024; 15 (1) DOI: 10.1038/s41467-024-53389-w
a neat paper where they used Rapa and also gene therapy to lower F-actin accumulation in the brain.
." By tweaking a few specific genes in aging fruit flies’ neurons, the researchers prevented F-actin buildup, maintained cellular recycling and extended the healthy lifespan of fruit flies by approximately 30%."
“Their first clue of a correlation: Flies on a restricted diet both lived longer and had less F-actin buildup in their brains. Their second clue: When treated with a drug known to extend lifespan, called rapamycin, there was also less F-actin in the brains of aged flies.”