Yes - Sea Squirts are not looking like a good long term solution unless you grew up in Korea and ate it as a child 
2 Likes
And the few times I was offered Sea Cucumber on business trips in China, I should not have passed.
“Sea cucumbers were abundant in ether phospholipids, especially plasmalogens”
1 Like
The paper cited at the top of this post noted that very specific plasmalogens were probably responsible for the benefit, and land-based animal meat does not contain them much.
Does anyone understand which of these fatty acids are most beneficial?
- 20:5 is EPA
- 22:6 is DHA
- 18:0 is stearic acid
- 18:1 is oleic acid
- 18:2 is linoleic acid
- 16:0 is palmitic acid
Sea food appears to mostly contain #1 and #2 (not surprisingly) but chicken and other meats contain 18:1 and others.
This paper seems to suggest that 18:1, 18:0, and 16:0 are ones frequently found in brains. But it didn’t look into DHA and EPA:
3 Likes
Looking at the table posted on May 11 (top post),blue mussels outperform ascidian (sea squirts) 2 to 1. Mussels are cheaper, and more palatable to the Western consumer.
You can get capsules of New Zealand green lipped mussel if you prefer the supplement route.
4 Likes
2 Likes
That is hilarious.
Clearly I’m deep into this now if I laugh at that. 
1 Like
1 Like
ProdromeNeuro is $199, ProdromeGlia is $99. How do you decide which one?
1 Like
Plasmalogens per se are vital membrane phospholipids in humans. Changes in their homeostatic levels my alter cell membrane properties, thus affecting key signaling pathways that mediate inflammatory cascades and immune responses. The plasmalogen analogs of PAF are also potentially important, considering that anti-PAF activity has strong anti-inflammatory effects. Plasmalogen replacement therapy was further identified as a promising anti-inflammatory strategy allowing for the relief of pathological hallmarks in patients affected by chronic diseases with an inflammatory component. The aim of this Short Review is to highlight the emerging roles and implications of plasmalogens in chronic inflammatory disorders, along with the promising outcomes of plasmalogen replacement therapy for the treatment of various PAF-related chronic inflammatory pathologies.
1 Like
More new research suggesting benefits for Plasmalogens:
A study of Alzheimer’s patients demonstrated that they had a 70 percent reduction in circulating plasmalogen levels compared to healthy people. This deficit of plasmalogen — which is one of the major components of biological membranes —appears to be specific for Alzheimer’s disease because it was not seen in other neurological conditions.
The earliest loss occurred in the brain’s white matter, which is not associated with dementia onset. Later loss of plasmalogen occurred in the grey matter, which causes the greatest dementia effect. Blood plasmalogen reduction of more than 75 percent was associated with the most decline in mental function.
And:
Marine resources contain unique glycerophospholipid plasmalogens and various valuable nutrients that could be beneficial for the prevention of age-associated diseases. A recent review published in the journal Molecules highlights the biological significance of plasmalogens and their relationship with age-associated diseases.
Paper (open access):
Marine Plasmalogens: A Gift from the Sea with Benefits for Age-Associated Diseases
Aging increases oxidative and inflammatory stress caused by a reduction in metabolism and clearance, thus leading to the development of age-associated diseases. The quality of our daily diet and exercise is important for the prevention of these diseases. Marine resources contain various valuable nutrients, and unique glycerophospholipid plasmalogens are found abundantly in some marine invertebrates, including ascidians. One of the major classes, the ethanolamine class (PlsEtn), exists in a high ratio to phospholipids in the brain and blood, while decreased levels have been reported in patients with age-associated diseases, including Alzheimer’s disease. Animal studies have shown that the administration of marine PlsEtn prepared from marine invertebrates improved PlsEtn levels in the body and alleviated inflammation. Animal and human studies have reported that marine PlsEtn ameliorates cognitive impairment. In this review, we highlight the biological significance, relationships with age-associated diseases, food functions, and healthcare materials of plasmalogens based on recent knowledge and discuss the contribution of marine plasmalogens to health maintenance in aging.
2 Likes
Wish the commercial price on Amazon was more palatable. Too much on my stack to take before it all expires. Does anyone have experience with this?
In-depth review reveals dietary lipid intervention as potential strategy to prevent brain aging
Dietary Lipid Intervention in the Prevention of Brain Aging
The review focuses on the intricate relationship between lipid homeostasis and brain aging, emphasizing the importance of maintaining synaptic plasticity to prevent cognitive impairment. By examining evidence from epidemiological and animal studies, the research team demonstrates the crucial functions of polyunsaturated fatty acids (PUFAs), specifically phospholipids such as phosphatidylcholine, phosphatidylserine, and plasmalogen, in promoting brain health.
Full (Open access) paper:
https://www.sciencedirect.com/science/article/pii/S2095809923002709?via%3Dihub
1 Like
A new option in the plasmalogen supplement market:
REMORY: Elevate Cognitive Health with Unique Sea Squirt-Derived Plasmalogens. Now in the U.S., this Japanese-Innovated Supplement Combines EPA, DHA, and Omega-3s
LOS ANGELES, CA / ACCESSWIRE / November 16, 2023 / REMORY®, a supplement known for containing plasmalogens, which are recognized for their role in preventing cognitive decline, has been launched in the United States. Since its introduction in October 2023, the product has received considerable attention.
Hokkori USA, a distributor known for its commitment to quality and customer satisfaction, has recently announced its role as the authorized distributor of a health product called REMORY®, a supplement known for containing plasmalogens, which are recognized for their role in preventing cognitive decline manufactured by Moolint, Inc.
REMORY® contains plasmalogens, components also found in the human brain, which play a crucial role in maintaining cognitive function. This supplement is particularly suitable for middle-aged and older adults who experience a decline in memory. Unlike other plasmalogens, REMORY® utilizes plasmalogens derived from sea squirts (ascidians), a source known for its rich content of not only plasmalogens but also EPA, DHA, and Omega-3 fatty acids. The primary ingredient in REMORY® is high-quality sea squirts sourced entirely from Hokkaido, Japan.
Furthermore, REMORY® is the only sea squirt-derived plasmalogen supplement in the U.S. market that has been granted permission by the Japanese Government to be labeled as a “Food with Functional Claims.”
Japan, facing rapid aging compared to other countries globally, has a high demand for products that help maintain memory, and many seniors have experienced the benefits of plasmalogens.
3 Likes
Interestingly sea squirts are one of the few animals to use vanadium-containing proteins.
Vanadium has been reported to lower blood glucose in various diabetic animal models.
2 Likes
2 dollars a day for this. If it works, then it’s probably worth it for me. If it doesn’t maybe I’ll forget the whole thing.
1 Like
I’ve been using the product below for over a year. Same dosage. Lower cost.
4 Likes
https://www.amazon.com/REMORY-Plasmalogen-Squirt-Supplement-Health/dp/B0CGY6T59K
1,000 ug (1 mg) per capsule.
Pardon the error. That was in reply to RapAdmin.
1 Like
What do you feel are your personal (albeit n=1) benefits from it? What is your age? Thanks!
Recommended by Dave Asprey (vanadyl sulfate).
2 Likes