Early Results From My Second Cellular Therapy

I’m two weeks out from my second cellular therapy, which included my first intravenous injection of a cellular product containing exosomes, growth factors, and MSCs. I thought I’d share an update because I’ve noticed some interesting changes.

I’m mindful that some or even all of these effects could be placebo, but my results so far align with anecdotal reports I’ve heard from others who’ve received similar treatments.

For context, last year I had an intra-articular injection into my right knee joint for persistent pain, which led to about an 85% improvement over seven months. At the time, an intravenous injection was also offered, but it was outside my budget.

This year, the company offered a deal that allowed me to receive both a localized shot in my ankle and an intravenous injection for the same price as last year. I was primarily interested in the intravenous injection, I saw the extra shot as a bonus.

The intravenous injection itself was quick, it took a couple of minutes. The nurse practitioner mentioned that I might feel either energized or experience flu-like symptoms afterward. I felt energized, and that feeling has persisted for the past two weeks.

I initially planned to wait longer before reporting, but my Oura ring has recorded some notable changes. The night of the therapy, my resting heart rate dropped to its lowest level in about a year and a half—the last time it was that low, I was doing extensive cardio.

My HRV, typically low for my age, also saw a significant increase.

Over the first week post-therapy, my nighttime resting heart rate dropped to this lower level four times, and although it’s mostly back to baseline now, it appears to be trending downwards.

Additionally, my Oura ring has shown an improvement in my resilience score, which has been steadily rising since the start of the month.

I’ve also observed a reduction in arterial stiffness as measured by my Withings Scale.

My arterial stiffness was previously in the optimal range before contracting COVID-19 for the second time—the take away here is avoid covid at all costs.

Here are some other subjective observations:

  • I have more energy and feel much more alert—it’s a noticeable change.

  • There’s been a significant improvement in my exercise capacity, particularly in terms of stamina. I’ve noticed this during cycling and sprints; I have more in the tank.

  • I’ve had residual balance issues since contracting COVID-19, and those seem to have completely cleared up. (I hope it’s permanent.)

I find all of this surprising, as my primary goal for the treatment was to address tendon issues. So far, there’s been no improvement in that area—I’m as sore as I was before the treatment.

While it’s still early, things seem to be trending positively. I know this isn’t a scientific assessment, but based on my reading. My personal opinion is that this might be one of the most powerful treatments available. Unfortunately repeated doses are currently out of my price range. I would love to see what effect regular injections every three months might have.

The good news is that the price is coming down. The nurse practitioner at the facility told me they were moving into a bigger facility so they can treat more patients as it’s proving so popular. Anyway, just thought I’d post if anyone is interested.

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Paul_2.0, I am interested in all of the injections, the knee injection, ankle injection, and intravenous injection. Can you give more detail about exactly what was in each injection. Specifically related to the intravenous injection what was in the exosomes and what growth factors were involved? Thanks.

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Yes, I received a localized injection of Wharton’s jelly, and an intravenous shot of purified Amniotic Fluid, which is a combination of Msc’s, exosomes and growth factors.

Paul_2.0, Yes, this sounds interesting. Keep reporting any effects you notice as you have time.

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What is the current price range for Cellular Therapy?

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I think it depends what state you’re in. Last year I paid $4500 dollars for a localized injection. This time around I got both for $5K. This is expensive. I wouldn’t have done it if I didn’t believe I’d get some real benefit. The nurse seemed to think that the prices will be coming down soon. She also mentioned that the FDA are close to approving these kind of treatments for diabetic ulcers, and it might not be too long before it might be covered by insurance. If that’s the case, then it will be available off label.

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Here’s another update on my cellular therapy. I’m now about five weeks out and so I wanted to post some new data and observations.

About two and a half weeks into the therapy my sleep began to improve, and for a period of about a week and a half I had the best sleep I’ve had since my youngest child-now ten-was born. I felt amazing, no more daytime napping and no afternoon drop in energy. I was regularly waking up feeling incredibly calm and rested.
I achieved by best readiness score in one and a half years of using my Oura ring.

Over the month of September my sleep duration improved by half an hour. I’ve regularly been sleeping for 7 and a half hours per night. I don’t remember the last time that happened.
At the beginning of this week, my sleep returned to back to my pre treatment levels for a few days and my nighttime resting heart rate was higher than normal.
It’s possible that I may have had a virus, as my kids both came home sick. I was feeling congested and had a mild headache for a couple of days.

However yesterday and today my nighttime resting heart rate went back down to 49 bpm and my HRV is back up again.

This affected my recovery score, but it’s beginning to trend upwards again.

The other noticeable thing is a reduction in my vascular age. it’s stubbornly been 47 years since I contracted COVID for the second time, hitting a low of 44 years. (this was my previous COVID level.
This seems to be trending back up again. I was hoping it would stay at pre COVID levels, it does fluctuate sightly so it’s possible that could still trend downwards.

The other really interesting thing is that there has been a reduction in the variability of my biological age on the Gerosense app. (I consider this a measure of my disease risk) Traditionally, and frustratingly my biological age is usually higher than my chronological age. Considering how much effort I put into trying to stay in shape, this annoys the hell out of me. Since the treatment there has been a clear reduction in age variation, it’s now tracking much closer to my actual age and so far this seems to be holding. This is by far the most interesting piece of data I’ve seen.

As you can see there’s a distinct downwards trend since I had the treatment on the 30th of Sep.

Unfortunately the app doesn’t allow me to go back and take monthly snapshots. But so far my age seems to have stabilized. it would regularly be 3 or 4 years higher than my chronological- and alarmingly the swings seem to be getting bigger. This is the metric I’m most intrigued by, I’m wondering whether or not I’ll continue to see less variation in my biological age. I would also LOVE to see if another treatment will lower It further -there’s no way I can afford it for at least a year. I have my doubts, but still really interesting to speculate.

Another thing that is notable, but may not be connected is that my total testosterone has gone up from 755ng/dl to 1012/dl in four months. I’m not sure it’s related, but I do wonder whether the improved sleep and high resilience score might be a factor.

As for my tendons, I still haven’t noticed any difference in my discomfort level. It’s possible, and probably likely that the MSC’s targeted critical systems and my tendons are way down the list.

That said, the nurse practitioner did say that I could expect to see improvement at the six week mark and I’m not there yet.

All in all, I think this is quite surprising and while I was expecting some positive results it’s encouraging to see such clear trends. If anyone has any questions let me know.

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Do you mean Total Testosterone?

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oops. Yeah, my bad. I’ll amend that. Thanks for catching it.