As the title states, does anyone know the dosage and schedule for Rapamycin that Dr. Sehgal used? It seems it was very effective.
Agreed. I’d be curious too.
I wonder if his son Ajai or wife Uma was aware of what the dosage was?
Wow. Thank you for this! It appears to be 1 mg a day. My father in law will probably be a bit more aggressive and take 1 mg + GFJ daily as he doesn’t have anything to lose.
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Yes - I typically see around 10mg/day for cancer treatments. Perhaps take breaks occasionally to ease up on the mTORC2 inhibition periodically.
5 days on and 2 days off?
I’m not sure. It might be more driven by side effects… from this 10mg/day trial:
The most common Adverse Effects (AEs) of everolimus therapy were laboratory abnormalities (100% of patients) and infection complications (83 episodes in 15 patients). Infectious episodes of pharyngitis (67%), diarrhea (44%), stomatitis (39%), and bronchitis (39%) were the most common infections. They were mostly mild or moderate in severity (grade 1–2).
From this study:
Complications of mammalian target of rapamycin inhibitor anticancer treatment among patients with tuberous sclerosis complex are common and occasionally life-threatening
Also, what are the results for the cancer patients you have heard about? How long do they survive?
That 10 mg is everolimus? Everolimus converts to Sirolimus in a 2:1 ratio, so that would be 5 mg/day of Sirolimus or 2 mg + GFJ
I have not looked at it in depth. I would search on “sirolimus” and the type of cancer your FIL has, in pubmed.
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Looks like I am going to be buying 1000 1 mg tabs of Rapamycin each year.
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do you have cancer??? I thought that once we take rapamycin regularly we are pretty much cancer free… so i thought. no old cells for the cancer to start with.
Not me. My father in law has cancer.
If I had cancer I will probably try the highest does I can tolerate until the test shows that it has decreased sufficiently to give me more time to go into a on/off type treatment. Anyway all the best.
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