What I meant is your trough could be normal if measured at 24 h.
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Yes.
I would expect to be in the normal range as it dissipates… until completely gone.
I personally believe it is that first blast number that dictates too much for the body. And, a negative effect. You won’t feel it… or even see it. But blood tests show it.
I only want a c-max of 6 to 12 ng/mL.
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Great info and thanks for sharing! What do you think about weight and dosage? In Matt K testing he uses weight for dosage in dogs?
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I agree that bigger people need slightly more… slim need slightly less.
Also, woman metabolize differently from men… and seem to need less. If a guy uses 6 mg… I would think a woman would use 4 mg.
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Have you seen any data on this in humans? Its a well-reported on phenomenon in mice as we saw in the ITP studies, but I don’t think I’ve seen any reports on this effect in humans.
Has anyone else seen any academic literature on different physiological effects of rapamycin in males vs. females?
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can you share what your supplements, scripts, diet and routine are like, personally. What have made a difference to you?
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This is just my best guess based on all the many podcasts and articles that i’ve read for the past three plus years.
We lack solid human trials… on dose.
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I think more importantly, we need to know whether there is a significant dose-response difference between men and women as that was a major factor in lifespan differences in mice.
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Professor Scolyer’s brain cancer is obviously horrendous. However, the cross disciplinary approach seems promising/interesting:
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Latest X from Dr. Blagosklonny:
https://twitter.com/Blagosklonny/status/1754673031253754066?cxt=HBwWpIO0zej07NkwAAAA&cn=ZmxleGlibGVfcmVjcw%3D%3D&refsrc=email
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Rapa turns off MTOR in an unnatural way; if you turn it on and off, you can break the switch
And this was a day earlier. Wondering why he cannot write a script for himself being an MD. Looks like he’s in search of medication.
https://x.com/blagosklonny/status/1754674717024202807?s=46&t=ujBXvjsf5sfNM8J1qi8RfQ
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You also may wonder, why his physicians are not providing the script.
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Hi, is your plan to reduce to 2mg of zydus + gfj?
I’m switching to zydus soon and basically want to copy what you’re doing😀
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Yes… I am now at 1 pill of 2 mg Zydus taken with one fresh squeezed Red Grapefruit … about 5 fluid ounces of juice. I get a 6 times increase. So I have 12 ng/mL in my blood after two hours per my Labcorp tests. Dosing every 10 days.
You can use store bought “Simply Grapefruit Juice” and get an equal benefit in dose increase.
At minimum you would get a 3 times dose increase… I tend to get more for some reason. Different phenotype. Still at 2mg and GFJ getting to 6ng/mL is great.
Staying on this program for now.
Retesting with GlycanAge and TruMe in a few months. See what is happening in my biological markers. I will share those results.
Good journey!
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Are young people’s cells biologically aging faster… so more likely to get cancer?
Hmmm… Rapamycin…clean up on aisle 4.
Glad my biological age is much younger. About 42 to 50 based on 3 different markers.
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Does anyone know how much Rapamycin Dr. Blagosklonny is taking? I would like to give the same regimen to my father in law for his cancer. Thank you.
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Yes, I know, a late reply. Well, again, those results are based on people using rapamycin daily to suppress the immune system. I would hope that intermittent use, with essentially “off” trough levels, is a different ball game, as that reduces the constant mTORC1 hyper-activation and inflammation the comes with aging, without suppressing the immune system. In fact, as I am sure most here would be familiar with, such use actually seems to improve the immune system.
I believe Dr. Blagoskonny had just recently before his diagnosis increased his dosage to 20 mg every two weeks, in an attempt to achieve high enough blood levels to get significant penetration of the BBB. Maybe a lower dose was keeping his nascent cancer (as he basically alludes to - spots on his lungs many years ago) at bay, and the higher dose was immunosupressive enough to have the opposite effect? Or maybe, it was just bad luck, something that even rapamycin wasn’t powerful enough to prevent.
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Decades of smoking isn’t just bad luck.
I doubt rapamycin played any part other than to possibly delay the onset of cancer.
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You wrote: Maybe a lower dose was keeping his nascent cancer (as he basically alludes to - spots on his lungs many years ago) at bay, and the higher dose was immunosupressive enough to have the opposite effect?
And is this reason why… when Blagosklonny was saying to all, go as high as you can. I think it was not the best advice… because when I went high for 7 months. I had problems with increased inflammation, and biologically aging, faster.
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