Right, but then you have to fast for 6 months (winter and spring) and then feast for 6 months (summer and autumn). Or how would you do a schedule?
So, some of you are going to take Rapa at near the immunosuppressant dose regiment?
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“activated more often as our body senses decline and tries to overcome this through MTOR activation”
This is a strong and interesting claim - what ARE the upstream effectors of this?
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EXACTLY! Feast summer-fall, low carb and maybe some fasting (depending on the individual) winter-spring…
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Thats very close to what @LaraPo uses for immune supression for her transplant maintenance. I’d be careful with the shorter dosing periods under a week, just because it can lead to mTORC2 inhibition and immune system supression.
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But this study B. mentions in his paper seems to propose daily schedule in healthy (elderly) adults is possible and does not show any adverse effects. Yes I understand it was only 8 weeks, but shows it could be possible? Or would you disagree?
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@RapAdmin, thank you for the warning. I will be exceedingly cautious sir. I will probably just see how it goes for a week or two of 1mg M-W-F and re-evaluate.
I just finished the first 7 days on 0.5 mg/day. I will break now for 3 days and will start again. No side effects yet.
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The difficulty with dosage is that we don’t know if the response in terms of autophagy is linked in a quasi linear manner with dosage or in fact to a higher power. It might be possible or even vaguely likely that a dose of say 8mg has more of an effect in terms of autophagy than a dose of 1mg.
re hyperlipidemia due to rapa;
We go to 2 Metabolic Health conf’s a year (aka low carb confs); the heart/metabolic speakers conclude:
- High LDL/lipids mainly are a factor if your calcium score is high.
- if your artery/heart calcium is low, THEN higher LDL/lipids is good news; many studies of higher LDL = lower diseases and heard speakers say lower covid when higher LDL.
Folks willing to DIY aging here all need to get their calcium scores and best to get whole body calcium scans IMHO
best to all, curt
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I think there is very minimal opportunity for rebound using weekly dosing. If you look at the graphs there is a slow gradual decline throughout the week due to the the long 62 hour T1/2, its not like you pulse and it is entirely cleared, frankly it is more like a steroid taper. That and I think Blagosklonny is thinking out loud and his comments should be taken as such. There are several, perhaps even 1/2 dozen researchers using weekly dosing in their studies and taking rapa weekly themselves that to me lends more credence to a weekly schedule than Blagosklonny’s thought article.
No disrespect but there aren’t any “new” findings here, I wouldn’t recommend changing to daily doses based on his comments.
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Can you share some more color on what this is? Can that be done without a lot of radiation?
You might imagine that like drugs, the medical device wars we never see many good technologies because the inventing company didn’t have the “in” with the FDA process or it got back burnered and something else was in favor… In this case what won out early was x-ray CT scanners. What was being looked at but took longer to get into patient facing facilities is a newer Electron Beam CT scanners. EBCT exposes the patient to 100th the radiation and 10x the resolution to x-ray CT (just what I was told).
Search your area for EBCT, the exact machine I was tested on was EBCT C300 scanner, developed by Imatron technologies.
Our Ca scores;
We’ve been eating paleo for 10yr, carnivore for 2, go to 3x Metabolic Health conferences (AKA low carb confs) / yr; all the research is pointing to carnivor is an ancestrally consistent diet with largely meat/fish diet, few vegies and maybe just asparagus / crusiferous (low/no oxalates - important - google high oxalate foods - another area we’ve been lied to re), Both my wife and my full body calcium scores are zero, big fat zero!!! At 69 yro that is pretty unheard of least in USA. Which was from a high fat and protein diet. Exactly opposite of American Heart Assoc (Duh) and American Diabetes assoc and toss in American Kidney assoc. All are wrong all are bought off by the low fat, statin, drug industries since low fat completes the circle of profitable American high inflamation state based diseases.
Sorry for the going off on low fat / allopathic medicine!!! Grrrr
Search for EBCT and get scanned. They often offer a loss-leader pitch, come in for a free heart scan. 
We paid $7k for life time per both of us to get every other year re-scans.
1 thing is better then 1 calcium scan, its 2 (or more scanns) separated by meaningful time. IE a bad score of 1000 is less bad if in 6 mo its stable and still 1000 (is the thinking). So we’ll get scanned every other yr. But watch youtube on dropping your calcian score there’s a protocol. It does include dropping your carbs (dropping inflammation via dropping insulin). Both of us wear CGMs for health monitoring. Not necessary! But a CGM is like this forum, its for serious and extreme practitioners. At least wear a CGM for 2 weeks and see your glucose variability (or hopefully not). Good luck to all, curt
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Very interesting. Thanks so much for sharing Curt.
Will def look into this.
Wonder why none of the imaging heavy longevity/specialist groups like Human Longevity/Health Nucleus, Fountain Life, Stanford spin-out Q-Bio or Prenuvo seem to offer this? They all operate outside of insurance and succeed or fail based on whether their offering is what their clients most like/perceive they get value from.
I did see that more and more people seem to think that this is a big leap forward vs traditional CAC/CT;
(Btw, I totally agree on CGM and totally love my Dexcom G6, though it does need some manual calibration for optimal measurements (haven’t tried G7 though))
Here are the providers that offer imaging in longevity context that I mentioned above in case of interest for anyone who was not aware (most here might already be aware of them given how well up to speed everyone is):
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There are some comments on Reddit which indicate some people think G6 is better than G7. I still have a couple of G7 sessions to use, but I want to time that around taking Rapamycin again. I have not yet scheduled another dose of Rapamycin.
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Just wanting to help bring the important point for this group back;
- If you have total cholesterol over 200 say. The level that age-irrespectively Drs will want you on statins.
the take aways we learned from 2 yrs of 3x Low Carb confs Dr/MD speakers who are on the leading edge of healthful practices are:
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Its healthier to have elevated cholesterol as you age. Covid stats where; folks with higher cholesterol had less, less severe, got less total diseases!! This is key!!! Its so frustrating to hear the anti fat, low cholesterol, pro statin practitioners. A friend; 70 yo femail, thin, healthy, cholesterol = 200, recently came home from her Dr getting ridiculed for not accepting a statin prescription. BTW Google side effects of statins (includes dementia and neurodegenerative symptoms).
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Cholesterol is the feed stock in the body for; Vit D, Testosterone and other steroid hormons. Not infering causation … but; fertility clinics are a booming business. Soy etc is not doing having babies any good either.
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Even hereditary super high cholesterol when studied through end of life does not (largely or as bad as current anti cholesterol thinkers would have us believe) predict early death or heart problems, Especially when negated by low calcium score.
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The punch line; Applogies for being tediously long winded. Low calcium score negates virtually all other risk factors and latest studies doubt any association with high LDL even small particle with much chardiac risk. Apo-B is much higher assoc with risks as high calcium (>600). A few Drs even saiid ignore high Apo-B if your calcium is low.
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That said; high Small particle LDL, high triglicerides / glucose / insulin to me is more an indication of a less then ideal diet that does have non-heart affecting negative consequences. JMO.
I’m pleased my cholesterol >200 and calcium = 0. What I picked up at conferences is get calcium scanned. Best to all, curt
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@curt504 with all due respect, a lot of what you’ve said or which you’ve found from conferences is contradicted by superior evidence in mendelian randomization studies and randomized controlled trials. A positive calcium score means atherosclerosis has progressed and there is advanced disease, if you want to avoid that you need to decrease amount of atherogenic particle count. To wait until a positive or high calcium score is missing the point.
This thread has discussed this question in detail, if you find this question important I suggest spending a few hours and reading this thread from the end and back:
A 0 calcium score is rare, and above 70 it becomes even rarer.
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@curt504 Sorry not to be up on things, could you point me to these latest studies? I thought high levels of small dense LDL was quite bad.
I have always had high cholesterol (210-260) regardless of diet or age (never tried keto). ApoB at 92. My doctor said not to worry because of the favorable ratios due to my high HDL. Never mentions statins.
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