Does Rapamycin inhibit MTORC2 thus inhibit muscle growth?

[Dripman]

Sarcopenia occurs in the elderly but can be combatted with proper exercise. Does rapamycin/sirolimus inhibit muscle growth by inhibiting MTORC2 which increases muscle growth?

[RapAdmin]

See this thread, we have discussed this a lot in the past. The answer seems to be “a little bit”. It you are a competitive bodybuilder it may be an issue, if not, then probably not a significant issue. Update on Brad Stanfield's Rapamycin Clinical Study in NZ - #182 by RapAdmin

[qBx123Yk]

Mtor1 is the one that drives direct muscle growth, mtor2 does so indirectly.

Also, inhibiting Mtor1 doesn’t shut down all muscle muscle growth pathways, it was demonstrated gaining muscle mass on some types of resistance training (exercises that emphasize muscle lengthening) is indepent of m-TOR 1.

Update on Brad Stanfield's Rapamycin Clinical Study in NZ

Agreed, there are some studies that show that although rapamycin seems to have a deleterious effect, after time has passed we find out that it has improved function. Here’s one example: https://www.sciencedirect.com/science/article/abs/pii/S0014299925007149 Yes, there are several, and it’s a fascinating subject : The role of mTOR signalling in the regulation of skeletal muscle mass in a rodent model of resistance exercise | Scientific Reports in this study, we investigated the role of rapamycin-sensitive mTOR in the RE-induced activation of muscle protein synthesis, ribosome biogenesis, PGC-1α expression and hypertrophy. The results indicated that the inhibition of rapamycin-sensitive mTOR could prevent the induction of ribosome biogenesis by RE, but it only partially inhibited the activation of muscle protein synthesis. Likewise, the inhibition of rapamycin-sensitive mTOR only partially blocked the hypertrophic effects of chronic RE. Furthermore, both acute and chronic RE promote…