Does Rapamycin effect Thyroglobulin?

.

Hello, all…

…I am on 6mg Rapamycin weekly, since November,

and just got my Endocrinologist blood work back,

saying that my

“Thyroglobulin LC MS MS”

was very high, at 7.2 -

and it was never elevated, before,

…although, as of probably 2 years ago was the last time I checked, because my Dr. got used to it being normal and didn’t expect any problems to come up…

…Everything I have read,

says this indicates

EITHER

C***** (I don’t even want to say it)

…or, an Autoimmune disease -

which I sometimes did have Neutrophils and Monocytes “off,”

even before Rapa -

so maybe it’s Autoimmune,

but…

…My mother (now deceased :frowning: ) ,

had her Thyroid removed, and it had abnormal cells (aka …Cancer :frowning: ) ;

Has anyone here, on Rapamycin Therapy, experienced that they developed elevated Thyroglobulin

(on the “LC Mass Spectrometry” test ;

not to be confused with the regular “Thyroglobulin without TG Antibodies” test)

?

Thanks to anyone who can share their experiences,

or just for reading my post…

.

I doubt anyone can tell you if rapamycin for sure has an effect on any given biomarker. There are however general principles, and that’s the only guide we have in these matters. Rapamycin is a immune system modulator. At doses that are not so high as to be immunosuppressive, rapamycin seems to have anti-proliferative properties. The signal seems to be, that rapamycin has cancer preventative effects, especially in certain classes of cancers. Once a cancer is present however, rapamycin is likely no longer effective. How that translates into your personal situation you must determine yourself, do you have extant neoplasms, precancerous conditions, are immune compromised etc. I am not aware of any effect of rapamycin on thyroglobulin, but I can’t say for sure, and I doubt anyone really can.

thanks @CronosTempi …and sorry i’m asking so many questions on here…

just if anyone else had this happen to them (thyroglobulin spectrometry went up after starting rapa), i hope to hear from them…

It doesn’t seem likely - but if you have any health issues rapamycin could function differently than for most people…

Here is what ChatGPT says:

Question: Does sirolimus impact Thyroglobulin levels?

ChatGPT said:

ChatGPT

There is limited direct evidence linking sirolimus (rapamycin) to changes in thyroglobulin (Tg) levels. However, sirolimus can affect thyroid function and immune responses, which may indirectly influence thyroglobulin levels in certain contexts.

Potential Mechanisms:

  1. Immunosuppressive Effects: Sirolimus is an mTOR inhibitor used primarily for immunosuppression in transplant patients. Since thyroglobulin is often used as a tumor marker in thyroid cancer or a sign of thyroid dysfunction, immune modulation could impact inflammatory thyroid conditions.
  2. mTOR Pathway and Thyroid Cells: The mTOR pathway is involved in cell growth and proliferation, including thyroid follicular cells. Some studies suggest that mTOR inhibitors may alter thyroid hormone synthesis and thyroid cell function, potentially affecting thyroglobulin levels.
  3. Impact on Thyroid Function: While sirolimus is not commonly associated with significant thyroid dysfunction, some reports suggest it may contribute to hypothyroidism or altered thyroid hormone metabolism, which could indirectly affect Tg levels.

Clinical Contexts Where This May Matter:

  • Post-Thyroidectomy Monitoring: In thyroid cancer patients, thyroglobulin is a key marker for disease recurrence. If a patient is on sirolimus, fluctuations in Tg levels should be interpreted with caution.
  • Autoimmune Thyroid Disease: If sirolimus modulates immune function, it could theoretically impact thyroid autoimmunity, affecting Tg levels in patients with Hashimoto’s thyroiditis or Graves’ disease.

Bottom Line:

Sirolimus does not have a well-established direct effect on thyroglobulin levels, but its immunosuppressive and metabolic effects might influence thyroid function in some patients. If you’re monitoring Tg levels while on sirolimus, it may be worth discussing with your endocrinologist to determine if any adjustments are needed.

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