i LOVE guanfacine because it can increase mental capacity and output while being the EXACT opposite of a stimulant
instead of making the brain a clusterfuck it decreases firing making you calm and clear headed instead of all over the place
- calm focus
- better working memory
- “zen” flow state
- better mental resilience to stress
- no hyperactivity
- less distraction
how the fuck does it do that since it literally decreases neural signaling?
guanfacine is a selective agonist of the α2A receptor, a receptor located primarily in the prefrontal cortex which could be named the “control conter of mental performance”.
activation of α2A by guanfacine results in less intracellular cascades going on that would normally make you stimulated.
it makes your brain less noisy so that you can think. clearly.
now you need to get the dosing right because it can be sedative at higher doses. anywhere in between 1-2mg is enough.
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I’ve heard good things about it. I’m about to trial some ADHD medication and this is something I’m interested in adding in conjunction with a stimulant.
selective agonist of the α2A receptor
Sounds good! Is there safety/longevity data on this?