Eg melatonin could maybe decrease it (though also make one more sleepy too). That said, past a certain dose higher doses of melatonin don’t seem to increase sleepiness, and vyvanse may just overcome this
Melatonin attenuates the amphetamine-induced decrease in vesicular monoamine transporter-2 expression in postnatal rat striatum - PubMed (10mg/kg melatonin)
Cardiac Early Repolarization Pattern Anomalies Among Children and Adolescents With and Without Attention-Deficit Hyperactivity Disorder: A Community Observational Study - PMC (I have early repolarization)
here’s a good dopamine researcher btw: https://cas.illinoisstate.edu/faculty_staff/profile.php?ulid=pagarri#fs-tabs-accord3
Tbf, I know that some of the “cool people” [eg one is noted EA/AI Safety person] just take it 1x-2x per week - usually this is enough to get people to do the “high activation energy” things they need to do while not making them tolerant/dependent and it most likely drastically reduces increased risk of Parkinson’s that could happen from taking it every day as prescribed. It’s also not 100% clear if occasional cycling (esp with co-administration of melatonin) causes any damage at all, since b/c hormetic effects.
https://twitter.com/search?q=%40typedfemale%20amphetamines&src=typed_query
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It’s also important to note that these things have appetite suppressant effects that can be pro-longevity on the rest of the body (esp if they are used to induce 48+ hour long fasts). Also it’s said by one person that using a lot of Vyvanse/Adderall seems to normalize the brain development of young kids with ADHD (at least the ones who are a mess without meds and whose brains then become ADAPTED to the condition where they’re constantly a mess - which screws up self-confidence and many many other things that are downstream)