I have a friend who is on antidepressant and reported that by adding a 10mg Vyvanse, it significantly improve the mood, energy and focus.
Most of my young and middle aged tech friends are on vyvanse or addie, at much higher dose though.
My hypothesis is that combining duloxetine (SNRIs) with low dose Vyvanse offers a more balanced approach for modulating neurotransmitters. SNRIs increase the levels of serotonin and norepinephrine via recycling, while the dopamine from Vyvanse can round out the remodelling by SNRIs, potentially providing a more beneficial neurotransmitter profile.
SNRIs increase the levels of serotonin and norepinephrine, low dose Vyvanse increase dopamine so the relative ratio of 3 is more balanced? Just a layman’s speculation.
I have found that a high dose of Adderall–30 mg or so–will interfere with, and impede, my ability to run. I think that Adderall either raises body temperature or makes the body more susceptible to increases in temperature.
I’m curious what the mechanism is here. My first thought is that stimulants help with positive/health promoting habit formation, as well as, perhaps, living a more purposeful life (due to increases in motivation and goal seeking). The second result about unintentional injuries makes me wonder though. Why do people with untreated ADHD injure themselves more often? Is that the bulk of the reduction in all cause mortality?
Looking more closely at the study, they only looked at people <=24 years of age. Not sure how relevant this is to long term use or conclusions about lifelong all cause mortality
People with untreated ADHD injure and kill themselves more often partially due to a wide range adrenaline-seeking behaviour and impulsive actions. Sometimes I’m amazed I lived long enough to be diagnosed and treated in later life.