The study examines how magnesium compounds, especially Magnesium-L-Threonate (MLT) and Magnesium-Acetyl-Taurate (MAT), affect neurophysiological functions in adult Wistar rats. Magnesium is essential for many cellular processes in the brain &...
Pharmacological modulation of circadian rhythms in brain microvasculature: https://doi.org/10.1177/0271678X251399116
Cognition-enhancing drugs: current landscape, mechanisms, and future prospects: https://www.sciencedirect.com/science/article/abs/pii/S135964462600070X
Attention deficit hyperactivity disorder (ADHD) is a disorder characterized by symptoms of inattention, impulsivity, and hyperactivity, which can significantly impair individuals’ quality of life and lead to various challenges in their social...
Lysosomes signal through the epigenome to regulate longevity across generations: https://www.science.org/doi/10.1126/science.adn8754
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging: https://www.science.org/doi/10.1126/science.adp5056
Longevity steps on the cGAS: https://www.science.org/doi/10.1126/science.aeb6125
The desire to increase life expectancy, coupled with the decline in biological functions that occurs as we age, represents one of the most significant challenges facing our society. Age-related declines in biological functions contribute to frailty...
Asthma and obstructive sleep apnea: A complex but treatable relationship: https://www.sciencedirect.com/science/article/abs/pii/S1087079225000991
Melatonin’s paradox: From therapeutic benefits to toxicity warnings: https://www.sciencedirect.com/science/article/abs/pii/S0009279725001863
Melatonin: beyond circadian regulation - exploring its diverse physiological roles and therapeutic potential: https://www.sciencedirect.com/science/article/abs/pii/S1087079225000760
Melatonin supplementation shows potential therapeutic effects in Alzheimer’s disease (AD) by targeting impaired neurogenesis. Neurogenesis, the formation of new neurons after development, involves proliferation, migration, differentiation, and...
The Therapeutic Potential of Melatonin and Its Novel Synthetic Analogs in Circadian Rhythm Sleep Disorders, Inflammation-Associated Pathologies, and Neurodegenerative Diseases: https://onlinelibrary.wiley.com/doi/10.1002/med.22117
Scalp hair repigmentation after radiotherapy: https://academic.oup.com/ced/article-abstract/50/11/2341/8163917
Gray Hair Repigmentation in Androgenetic Alopecia Under Oral Minoxidil: https://onlinelibrary.wiley.com/doi/10.1111/ijd.70431
Antagonistic stem cell fates under stress govern decisions between hair greying and melanoma: https://www.nature.com/articles/s41556-025-01769-9
Hair Repigmentation Outcomes in Patients With Graying Hair Treated With Exosome Therapy: A Cross-Sectional Observational Study: https://onlinelibrary.wiley.com/doi/10.1111/jocd.70526
Ergothioneine regulates the paracrine of dermal papilla cells through SIRT1/Nrf2 pathway to antagonize oxidative stress and natural hair follicle aging: https://www.sciencedirect.com/science/article/abs/pii/S0891584925007257
FOXOs constitute a class of evolutionarily conserved transcription factors that play pivotal roles in diverse cellular processes, including glucose and lipid metabolism, energy homeostasis, oxidative stress response, and autophagy. They are...
Polyphenols are emerging as promising candidates for promoting healthy aging and neuroprotection. Here, we investigated the effects of quercetin (Q), luteolin (L), and 3-O-methylquercetin (3OMQ), individually and in combination (FORM), on lifespan,...
As a target organ in direct contact with external air, lung tissue is more susceptible to aging, and lung aging is closely related to the development of chronic lung diseases such as chronic obstructive pulmonary disease and pulmonary fibrosis....
Aging not only significantly reduces the quality of life for the elderly but also poses multifaceted challenges to society. Its progression involves the synergistic interaction of multidimensional, multipathway molecular mechanisms, including...
To verify whether DNA repair is regulated by FOXO3a, a tet-on flag-h-FOXO3a transgenic mice were used. RT-q-PCR and western blot analysis showed that the mRNA and protein levels of flag-h-FOXO3a, XRCC4, XPC, APE1 and MSH2 increased dose dependently...
Age-related renal impairment often occurs insidiously and has become an important cause of chronic renal failure, especially when individuals with other chronic diseases. However, there is lack of effective treatments. Research on diabetic patients...
Sleep deprivation (SD) and aging are linked to chronic inflammation, a contributor to age-associated diseases. Circadian rhythms, governed by suprachiasmatic nucleus (SCN), regulate immune and inflammatory responses. While aging and SD elevate...
Naringin is an antioxidant flavonoid rich in diverse plant species, including citrus plants. While the antioxidant activity of naringin is well documented, there has been limited research on its anti-aging potential. The aim of this study is to...
Cytomegalovirus (CMV) drives immunosenescence, while its reactivation is associated with inflammation and oxidative stress. This study investigates the interplay between CMV, oxidative stress and inflammation in a cohort of 2065 age-stratified...
With the aging of the population, frailty has become a common syndrome that severely affects the quality of life of older adults. This study aims to analyze the correlation between cognition and frailty, physical activity and frailty, and elucidate...
