Do you have any labs besides these that you would want on a future rapamycin patient?

  1. Blood sugar level tests:
  • HbA1c
  • Insulin
  1. CBC with differential typically includes the following components:
  • Red blood cell (RBC) count
  • Hemoglobin (Hb) level
  • Hematocrit (Hct) level
  • Mean corpuscular volume (MCV)
  • Mean corpuscular hemoglobin (MCH)
  • Mean corpuscular hemoglobin concentration (MCHC)
  • Platelet (PLT) count
  • White blood cell (WBC) count
  • Differential white blood cell count
    • Neutrophils
    • Lymphocytes
    • Monocytes
    • Eosinophils
    • Basophils
  1. Kidney function tests:
  • Blood urea nitrogen (BUN)
  • Serum creatinine
  • Glomerular filtration rate (GFR)
  • Cystatin C
  1. Inflammation markers:
  • C-reactive protein (CRP)
  • Interleukin 6 (IL-6)
  • Tumor necrosis factor alpha (TNF-alpha)
  • hsCRP (high-sensitivity C-reactive protein)
  • Erythrocyte sedimentation rate (ESR)
  1. Vitamin tests:
  • Vitamin D
  • Vitamin B12
  • Folate
  1. Iron level tests:
  • Fe level
  • Ferritin
  1. Lipid level tests:
  • Lipid panel
  • Total cholesterol
  • HDL cholesterol
  • LDL cholesterol
  • Triglycerides
  • Non-HDL cholesterol
  • Lipoprotein (a)
  • Apo-B (Apolipoprotein B)
  1. Liver function tests:
  • Alanine aminotransferase (ALT)
  • Aspartate aminotransferase (AST)
  • Alkaline phosphatase (ALP)
  • Bilirubin
  • Gamma-glutamyl transferase (GGT)
  • Prothrombin time (PT)
  • Albumin
  1. Hormone level tests:
  • Free testosterone test
  • Sex hormone binding globulin (SHBG) test
  • Luteinizing hormone (LH) test
  • Follicle stimulating hormone (FSH) test
  • Prostate-specific antigen (PSA)
  1. Cardiac markers:
  • Troponin
  • Creatine kinase-MB (CK-MB)
  • B-type natriuretic peptide (BNP)
  • N-terminal pro B-type natriuretic peptide (NT-proBNP)
  1. Pancreatic function tests:
  • Amylase
  • Lipase
  • Trypsinogen
  1. Autoimmune tests:
  • Antinuclear antibody (ANA)
  • Rheumatoid factor (RF)
  • Anti-cyclic citrullinated peptide (anti-CCP)
  • Anti-double stranded DNA (anti-dsDNA)
  1. Allergy tests:
  • Skin prick test
  • Blood IgE test
  1. Cancer biomarkers:
  • Carcinoembryonic antigen (CEA)
  • CA 19-9
  • CA 125
  1. Blood lead level (BLL) test

I’m not sure Vitamin B12/folate/iron/ferritin, GGT/PT, hormone levels/cardiac markers/pancreatic/autoimmune/allergy/cancer markers/BLL are needed or where the significant utility is, can you elaborate?

Personally, Vitamin D assays can vary too much, individual can vary, seems unnecessary to do beyond a few times at best (as optimally as possible with the “right” assay) to get it between 30-40 ng/dL.

Lp(a) one-time at best for cost-effectiveness unless suspect erroneous results. ApoB can sub for standard lipid panel and vice versa. Not sure I’d test CRP/ESR/TNF-a/IL-6 vs hs-CRP only (I’d retest 2 weeks if suspect erroneous results personally). Maybe fasting glucose as opposed to fasting insulin + glucose. Frankly, I’d be more concerned for false positives esp autoimmune tests.

I’d be more into testing fasting IGF-1 and lean body mass via DEXA (preferably with good visceral fat estimates).


After creating the list, I think a lot of it is overkill.