Do we have any data in mice about how Rapamycin affects different hallmarks of aging?

#1

  • DNA damage: increases Cap Independent Translation proteins (which probably improve Direct Reversal), almost no data on other DNA repair pathways

  • Telomere length: no difference/ slight decrease

  • Epigenetic clocks: almost no difference, some studies show some slowing down

  • Loss of proteostasis: improved autophagy (probably the main reason why Rapamycin increases lifespan)

  • Mitochondrial DNA damage: very strong decrease in rate of new mitochondrial mutations

  • Cell senescence: decreases SASP

  • Stem cell functions: improvement

  • Somatic mutations: do we have any data about this?

  • NHEJ and HR (double strand breaks repair) - do we have any data about this?

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