Do some users on this site get stronger benefits from rapamycin?

#1

I’m a bit surprised that how great a difference of rapa benefits are expressed on this site. What I have gained in my first year and over past 4 years versus hearing others feel very little or no benefit.

This recent study on rapamyacin and genetic differences in flies may help understand why so much difference exists. Indeed, even in a group of genetically different flies, some benefit a lot… some benefit a little and some seem to benefit the least.

Link: https://onlinelibrary.wiley.com/share/FUWMHSIRJCJFWWG7CZBB?target=10.1111/acel.14328

I’ve often said that my genetic makeup and having O+ blood makes a big difference in for me.

As was mentioned during COVID that O+ positive blood persons were less like to catch the disease and when infected had minimal lower symptoms… quick recovery.

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#2

I have O+ blood also. Blood Connections loves me.

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#3

O+ too. For me it seems like wound healing and blood flow.

#4

O negative for me.

A problem many of us face in assessing rapa benefits comes from us biohacking or using various drugs, supplements, or molecules in a longevity stack.

This makes sense to do, for a couple of reasons.

  1. Things we do act through different pathways.
  2. One life only enables us to do N-1 experiments.

I’ve taken up rapa for the long haul seeking whatever protection I can get from heart disease, cancer, and dementia.

I did drop some weight and body fat starting some 3 months into dosing, but not as much as you or doctor Greene have reported.

Hmmm… - maybe time for me to look at increasing dose or adding grapefruit juice?

@Agetron - What’s your current stack?

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#5

I’ve never seen any indications of different blood types responding differently to rapamycin. Therefore, I’m curious what makes you think O+ blood has anything to do with the degree of benefits you appear to get from rapamycin?

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#6

Here is one research on the topic.

“We found slightly increased infection prevalence among non-O types.”

Link: Testing the association between blood type and COVID-19 infection, intubation, and death - PMC

Granted this relates to covid infections but would it not relate to other blood interactions with molecules like rapamycin and diseases.

Mainly pointing out that blood type could indeed affect a person’s body response to rapamycin.

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#7

I’ve seen this link before with COVID. I agree that blood groups could certainly influence other things, including the body’s response to rapamycin. However, I have not seen any evidence of this and if there are some significant differences between people based on blood groups, who is to say it’s in the direction of being beneficial for group O? It might as well be the opposite.

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#8

As I have mentioned, I think it is obvious that older people such as Dr. Greene and myself will have more measurable and subjective benefits than younger people.
However, if you want maximum lifespan start taking it earlier in life even if you don’t experience measurable or subjective benefits.

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#9

I also have O blood. However, I did get COVID twice. The first time was quite bad. The second not so much. We each have individual biologies that cause us to react differently to different treatments. Part of the magic is finding out what works for you.

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#10

Yes, my point wasn’t that, O+ positive blood is the lucky lottery winner of blood types, just making a point that specifically with COVID that blood type was brought up very early as a phenotype that could benefit. It may equally, at another time, be detrimental.

My son, who’s O+ positive, has a positive and a very quick response to rapamycin, and maybe others find that true, too. Kind of interesting to see on here.

So many various trials that could be used to determine who and what and how one benefits from use of rapamycin.

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