Avoid the following supplements
Calcium - 30%-90% greater incidence of heart attacks. If you take it, must pair with vitamin D. Calcium through diet is beneficial. Calcium supplements are beneficial for vegan women who don’t consume dairy.
Iron - only supplement if deficient. Best to get through diet
Vitamin E - increases mortality and reduces effects of exercise. Increased risk of prostate cancer.
Vitamin A -
Resveratrol
Thx. For that reason, I never took calcium until this fall.
I was advised to take it for my early stage osteoporosis, and while it’s probably the right thing to do, I wince each and every time I pop one of those pills!
(I also take a lot of K which is supposed to make sure it goes to the right place… fingers crossed!)
According to Dr. Brewer, Simvastatin causes memory loss at higher doses.
calcium alpha ketogutarate is not calcium right? its an ingredient in novos I take
@sunshine4 The calcium in CA AGK is indeed regular ol’ calcium
For example, the calcium content in do not age’s product is aprox 75mg of calcium. It’s aprox 65 in renue by science. I recently found this out in order to manage my total calcium intake.
Years ago, my mother was prescribed amitryptyline (sp?). Her mother was still of pretty clear mind at the age of 100, but my mother declined cognitively at a fairly young age (70s). I do think the meds had some effects on this. She had a difficult time when she lost my dad too, when she was 75. Her hair turned white overnight.
If you want to waste time and learn nothing I can recommend this terrible yt video. In fact you get to listen to inane and actually wrong statements. Dr. Carvalho is usually quite sensible and provides good information, so I’m surprised at the listless and mediocre performance here. Dr. Brad is an enthusiastic speaker as usual, but surprisingly imprecise about rapamycin (though accurate about metformin and the rest), and Nick, unsurprisingly is his usual combination of smug and useless - I know he has many fans here, but I’m not one of them, having caught him making many stupid and wrong statements, he does love himself though. So if you want to hate watch:
Fact-checking anti-aging meds | Metformin, Rapamycin, NMN, etc
What are you doing to control asthma? I’m using steroid inhaler and a rescue inhaler as needed.
Luckily I don’t have any concerns with Asthma.
A common ACE inhibitor, Lisinopril, that is commonly prescribed to patients with high blood pressure can cause higher incidence of stroke death compared to other BP meds.
Ok but notice the final sentence of the abstract:
“Most of the evidence suggests that this kind of supplementation does not potentiate muscle growth and could possibly attenuate hypertrophy over time.”
Also, can we really call an overview of 3 studies a “meta-analysis”? I guess so, strictly speaking, but it certainly points to the need for more research in this area. I really wish we had something on more complex (yet still standardized) antioxidants such as Pycnogenol and resistance training.
Or for that matter, foods high in antioxidants. Should we avoid dark berries and green leafy vegetables before exercise for optimal hypertrophy? How about adding in a dash of pro-oxidants just before resistance training to augment gains?
Indeed, the authors contradict themselves several times in their own study.
Here’s a very short video from Siimland discussing supplements and meds that may not be beneficial. I disagree with Metformin though as it is synergistic with Rapamycin.
DeStrider, thank you for this!!! What an important nugget of information for us! Fortunately, I seem to sleep fairly easily, but if I couldn’t, it would be a huge temptation to use Ambien or something like it. Lifechanger…
I find CBD/CBN also helps me sleep really well and from what I have read this wont interfere with the glymphatic system. Certainly the next day I feel refreshed -and usually beat my mathematician husband at chess! So My cognitive is fine.
The problem with Metformin is that it seems to lower my testosterone levels.
Also worth mentioning ACE inhibitors didn’t show lower risk of death in the 2024 UK Biobank data and actually showed a (slightly) faster risk. I see no reason for anyone to use an ACEi over an ARB.
“As our findings suggested that there may be a drug class effect on mortality, we performed a pooled analysis, combining drugs from the same class (Methods). We selected Statins, PDE5i, Estrogens, given that we observed some positive effect on survival for some of these drugs. We added SGLTi, and Metformin, due to previous reports of positive effect, and ACEi due to potential reports of positive effects (Figure 5, Data Table 5). Statins (HR 0.97, Cl 0.94-1.00) and Estrogen (HR 0.76, Cl 0.67-0.85), as a class, reduced mortality, so did SGLT2i (HR 0.64, Cl 0.45-0.89), although with a much lower sample size. Metformin (HR 1.01, Cl 0.95-1.07) had a neutral effect on mortality, while ACEi (HR 1.11, Cl 1.06-1.15) was associated with increased mortality.”
Taking tyrosine is probably a bad idea if you are a man. It could take a year off your life!
In patients with chronic liver disease, elevated serum tyrosine is also a risk factor for development of hepatocellular carcinoma and mortality:
