IIRC you take Trazadone, why not just take another dose of Trazadone when you wake up in the middle of the night? (Probably you’ve tried this and it didn’t work)
I tried it but it made me drowsy and slow to start my mornings. It also isn’t a slam dunk to work since I notice my body builds a tolerance to Trazodone, unfortunately. With the ambien, the effect seems to be really fast acting. Like, enough for a nap but not a full night of sleep. That’s how my body handles it at least.
3 Likes
There are different physical forms of vitamin E. Only some occur naturally in foods and are used in our bodies. Most commonly natural supplements are exclusively or predominately composed of d α-tocopherol where the d refers to the Latin word for right. It is much cheaper to make vitamin E synthetically from petroleum than to derive it from biological sources that would yield just the natural d alpha form or d alpha along with other natural but probably less common forms. Similar differences are found for other molecules. I stick to the more expensive formulations of natural molecules. I think it is less risky. Some research agrees with this, some does not. At least 20 years ago there was a debate about whether vitamin E would reduce cardiovascular disease and/or blood clots. There was a large physicians study that rejected a positive cardiovascular role for Vitamin E. A large nurses study that examined blood clots as well as cardiovascular disease was published later. The latter found no negative effect on cardiovascular disease but a notable positive effect in women who were genetically susceptible to blood clots. The doctors used a synthetic version; the nurses a natural-it is unclear whether this made the difference in their findings. It could also have been due to differences in gender since at the time gender sharply distinguished these professions. There was a similar debate about forms of estrogen — here the lit on these chemically slightly different forms finally was eventually relatively clear that the similar but slightly different cheap estrogen derived from mare’s urine was not a healthy replacement for natural estrogen as found in the human body.
Oat pesticide causing fertility issues.
So what you’re saying is that the small amounts of pesticides in these foods act as a hormetic stimulus for longevity, and as we know longevity is linked to low fertility🤣…/jk/
It’s a growth regulator, not a pesticide. The suffix cide means “to kill”. Nothing is being killed here. It makes plants shorter so that they don’t fall down from wind or the weight of the grain.
I don’t know why they don’t just buy oats from here where nobody has even heard of this stuff. We buy oats for the goats from neighbors and they are clean and cheap. It’s easy to raise pesticide free oats because they grow so fast and are drilled, so cover the ground fast. Story makes no sense.
1 Like
Interesting list of things causing liver injury to the woman in question. I’ve literally taken all of those things. Turmeric, ashwaganda and horsetail are daily supplements for me. (These days I call “daily” 5 times weekly with rest days on Wednesdays and Sundays. But for the first 25 years of so of supplementation, it was literally 7 days a week.)
Though I’ve taken kelp in the past, these days I get iodine via Lugol’s solution–seven days a week on that one. All of these things go back decades for me. I’m 68 but have been heavily into supplementation since my early 20s. Resveratrol was more recent, of course, since it wasn’t around back then, though that’s been more like only twice weekly intake and some periods of not taking it at all.
Also calcium was mentioned in a prior post above as another no-no. I take that daily as well, though with magnesium, silica, K2, etc. This dosing goes back decades, too.
My liver enzymes are usually much like my last blood test from four months ago. AST - 19, ALT - 21, GGT - 14. All super low. I do take liver-healthy milk thistle supplement and take trimethylglycine which should help with liver methylation, so those might help account for my apparently very healthy liver. But I also think the supplements in question are not all that problematic for most people.
I had a calcium scoring exam about a year ago. My doctor took one look at that and said, “Well, maybe in a hundred years or so you might have a minor concern with calcium build up.”
I also take 300 mcg of melatonin nightly, which was also mentioned in other posts above as a potentially problematic supplement. I’ve never had any issues with it. That dosing goes back about 25 years.
So I wouldn’t take one person’s bad outcome, like that of the Nutrafol consumer noted above, and put too much stock in it. If a bunch of people had the same result, that’s another story, of course. But plenty of people, like myself, have no such issue with the supplements mentioned, even with long term daily or near daily usage.
2 Likes
- Resveratrol
- Metformin for non diabetics
- Vitamin C
- Vitamin E
Makes me want to dump all my leftover Resveratrol down the drain.
3 Likes
I doubt these four supplements negatively impact longevity.
Watching the video:
(1) ‘Blunting’ effect of exercise from resveratrol: baseline characteristics are different so the groups aren’t equal. The placebo group was leaner and fitter to begin with.
(2) The effect on testosterone levels – the study was in women with PCOS which can’t be generalized to men
(3) Metformin study ‘blunting effect’, is bad. Why? The Metformin group had a baseline glucose of 150 mg/dl, while the exercise only group had one of 100 mg/dl! They didn’t even randomize. It was just people who were already taking metformin in the exercise+metformin group, and the exercise only group with those who didn’t take metformin.
(4) The testosterone study for metformin had a decrease of -10%, not clinically significant. I didn’t look at anything else.
To sum up, no resveratrol or metformin does NOT negatively impact your longevity based on what was claimed in the video.
6 Likes
I did that couple of years ago
3 Likes
It helps to be skeptical even of the skeptics and be symmetrical in what evidence is required both for and against.
2 Likes
This meta-analysis seems to indicate no effect, positive or negative for vitamin c and e supplementation and strength or hypertrophy training.
Regarding the effects of antioxidant supplementation on strength gains, six studies reported data and the results of four of them [28, 30, 34, 35] indicate that vitamin supplementation has no influence on strength gain. Within these six studies, meta-analysis was done with the three studies that employed isokinetic assessment of muscle strength [33–35]. Results of the meta-analysis confirmed that supplementation is innocuous regarding this outcome (Figure 2). In other words, vitamin supplementation was neither positive nor negative.
Two studies analyzed muscle mass adaptations in young men and women, and they found no effects of supplementation.
3 Likes
Avoid the following supplements
-
Calcium - 30%-90% greater incidence of heart attacks. If you take it, must pair with vitamin D. Calcium through diet is beneficial. Calcium supplements are beneficial for vegan women who don’t consume dairy.
-
Iron - only supplement if deficient. Best to get through diet
-
Vitamin E - increases mortality and reduces effects of exercise. Increased risk of prostate cancer.
-
Vitamin A -
-
Resveratrol
4 Likes
Thx. For that reason, I never took calcium until this fall.
I was advised to take it for my early stage osteoporosis, and while it’s probably the right thing to do, I wince each and every time I pop one of those pills!
(I also take a lot of K which is supposed to make sure it goes to the right place… fingers crossed!)
1 Like
According to Dr. Brewer, Simvastatin causes memory loss at higher doses.
calcium alpha ketogutarate is not calcium right? its an ingredient in novos I take
@sunshine4 The calcium in CA AGK is indeed regular ol’ calcium
For example, the calcium content in do not age’s product is aprox 75mg of calcium. It’s aprox 65 in renue by science. I recently found this out in order to manage my total calcium intake.
3 Likes
Years ago, my mother was prescribed amitryptyline (sp?). Her mother was still of pretty clear mind at the age of 100, but my mother declined cognitively at a fairly young age (70s). I do think the meds had some effects on this. She had a difficult time when she lost my dad too, when she was 75. Her hair turned white overnight.
If you want to waste time and learn nothing I can recommend this terrible yt video. In fact you get to listen to inane and actually wrong statements. Dr. Carvalho is usually quite sensible and provides good information, so I’m surprised at the listless and mediocre performance here. Dr. Brad is an enthusiastic speaker as usual, but surprisingly imprecise about rapamycin (though accurate about metformin and the rest), and Nick, unsurprisingly is his usual combination of smug and useless - I know he has many fans here, but I’m not one of them, having caught him making many stupid and wrong statements, he does love himself though. So if you want to hate watch:
Fact-checking anti-aging meds | Metformin, Rapamycin, NMN, etc
1 Like