I’m going to try a rapa toothpaste and have a question for the group: can the crushed rapa be mixed with baking soda and left in a dry state? Must it be dissolved? Any thoughts from the group?
I haven’t sourced transcutol yet. If you’re considering it, DO NOT USE DMSO. Tastes horrible.
I stopped using toothpaste years ago because of a sensitivity to Sodium lauryl sulphates (which are in everything) and was tired of paying 4x $ for ‘natural’ toothpastes. I currently use a plain toothbrush and a spritz of essential oil minty breath spray. Most of my gum sensitivity is gone, and I rarely have canker sores, a chronic problem since childhood.
I don’t think you want to use it without something that helps with absorption in skin:
Sirolimus (rapamycin) is a mammalian target of rapamycin (mTOR) inhibitor with antiproliferative, antiangiogenic, antifungal, anti-restenosis and anti-inflammatory properties. However, its clinical application is often hampered by poor aqueous solubility
Source: https://www.tandfonline.com/doi/full/10.1080/21691401.2017.1408123
Transcutol is easy, cheap and what I’ve used without problems and tasteless from what I could tell.
Instead of a toothpaste, could you just take your weekly rapa as a mouthwash? (rapa dissolved in water, swish it around your mouth and then swallow it)
Approaching 11 months using a DIY rapamycin toothpaste.
Prior to starting I had a full dental workup and the photos showed red inflamed gums (periodontitis and not a pretty thing) around all my back teeth.
My teeth would get sensitive to various things, leading me to sparingly use clove oil to turn down the sensitivity.
Today I received a clever dental mirror with an LED light.
Brilliant thing.
Absolutely no sign on inflammation.
Just healthy looking gums.
Maybe not definitive.
Maybe taking Rapamycin orally has helped too.
Can’t think of any reason to stop.
I (with this forums great guidance and feedback) just biohacked away a major health and longevity risk.
I used the same jarred toothpaste as RapAdmin in his 1st post above, a bit of Transcutol, 10mg Rapamycin powder from a compounding pharmacist, and a few drops of peppermint.
Rapamycin can’t do everything, but wow!
I’ll report more specifics after my next check up.
Several months ago, I bought 150 Siroboon 2mg rapamycin pills. As written about on the site, it turns out not much of the Siroboon gets into the blood (so don’t buy it!). But, someone did post a lab report on the Siroboon and it does contain rapamycin (the thought is that the coating does not work and most of the rapa gets destroyed in the stomach).
Anyway, with a bunch of unused Siroboon, I decided to use it for brushing my teeth.
Very simple- I crushed 20 pills (40 mg) into a fine powder and I dip the toothpaste on my toothbrush into that powder, picking up a light dusting. And then I brush my teeth. I use it only once per day - before bed. I’m guessing I might be using 6 mg per month (about .2 mg per day). Of course I spit it out when finished brushing (1 - 2 minutes), but don’t rinse. I would think very little enters circulation.
My “periodontal” gaps were quite high, but after taking rapamycin (orally) for six months they were reduced by 40%. I’m hoping the brushing will improve upon that.
Will it make a difference? I’ll report back after my next cleaning.
Its been a few years since I researched this, but transcutol is a very safe product from what I’ve read. Its regularly used in oral medication formulations. As a toothpaste or flossing paste, I use a small amount - under 5% of the total formulation, and of course most of it I spit out after brushing or flossing.
the estimated oral Permissible Daily Exposure Level of 10 mg/kg/day
