@scta123 I had no reason to record that article because i have enough sense NOT to use rapamune tablets ever for anything much less pay 100 times the price for rapa. You do your search and find that article if you want to use that. Why on earth would you do anything other than use the pure powder ? If i had to pay that gigantic price for rapa i would never be using it.in the first place. But i tell you that is what the article read - number 1 was using micellar water alone. For one thing that should be obvious is you are sure not going to get a nano nor even micro sized… micelle… nor emulsion by trying to mix crushed rapamune tablets with a viscous face or skin cream. That article u quoted has nothing to do with rapamune tablets which should have been obvious. If it isn’t obvious to you the first prescription i quoted also has nothing to do with rapamune tablets. Those are 2 different unrelated issues i posted. The first to show there are many prescriptions that don’t use either dmso nor transcutol which had NOTHING to do with rapamune tablets. The 2nd was to do with using rapamune tablets in the case of a comparison experiment or report that was done. Seems u have a lot of study to do. Crushing rapamune tablets using pistil and mortar and the article you mentioned is like comparing something out of the stone age to technology of the 21st or 20th centuries. The stone age did not even know about even …micro nor micelle etc. Ofcourse that article you mentioned has nothing to do with the one i mentioned concerning rapamune tablets. What is your main reason for using a rapa cream or gel or ointment in the first place ? If its for a specific issue, other than to do with say trying to get repigmentation of hair, like i said u will likely be better off using tacrolimus and/or 4-ethoxybenzaldehyde.In case u didn’t know tacrolimus is also used just like rapa for organ transplant rejection.
I have as yet never read anything about anyone who was ever damaged nor even noticed dmso carrying other things into skin or whatever.
I wish I could get sirolimus powder, but unfortunately it is not available in Europe to my knowledge. You cannot order medicines from outside EU, they get confiscated by customs…
Don’t you even realize how small 1mg of rapamycin is?
You would have to pay for 100 milligrams to have even a workable amount. Compounding pharmacies are NOT supplying pure rapamycin powder. They have to dilute it with excipients to make it practical to work with, make it into pills, or encapsulate it. I am not sure that the compounding pharmacies are receiving pure undiluted rapamycin. If they do they are not selling it to you. If you can prove otherwise I will stand corrected.
that was just my point to the person who seemed to think otherwise. i don’t deal with compounding pharmacies. i ordered 5 grams NOT mg at a time from mesochem
so in that case it seems u would also have same problem getting tablets eg rapamune or other from India
I can get prescription rapamune in local pharmacy. That is all what is available to me. I can also order sirolimus ointment/cream in desired concentrations but it is just mix of some sort of basic pharmacy ointment and powdered sirolimus. No penetration enhancement. That is why I would want to make my own. If I travel to somewhere where I can order powdered rapamycin, I might get some.
Charles Brenner tells us we should be adding NR to our skin cream. Apparently it increases elasticity or something like that.
Crushing rapa tablets which is what the compounding pharmacy did is crushing the other things besides rapa in the tablets mostly as the rapa is
only a very small percent of the total like 1 or 2mg or so depending upon the particular pill/tablet or whatever. Most likely for lack of better words the rapa is ’ microscopically coordinated ’ with whatever in some way and one is NOT going to undo that to get the pure rapa which is what is used in the superior penetration articles by some heathan method of crushing tablets which is macroscopic. Those articles with the superior penetration are from micellar and/or emulsions and micro encapsulated… often in the nanometer size range but not always but at most a few hundred micrometers. So most all the favorable things it says using transcutol and/or whatever or even dmso to get micro encapsulation is NOT going to happen by using/crushing tablets such as rapamune or whatever. Those using transcutol or whatever there are always other things also besides transcutol or dmso etc and any significant favorable penetration is not going to happen by starting off with only crushing tablets in the way that the compounding pharmacy or u or anyone else does.
don’t know what exactly is NR but applying a solution of urea to skin prior to applying what ever will likely help more.
I am blessed not to have many wrinkles but I do have frown lines on my forehead and I never had Botox and am thinking about it as I am out in the sun a lot hence the squinting. But I don’t want to have to do it over and over again with Botox. Any suggestions or better alternatives?
My sense is that sunscreen rigorously applied is the best thing you can do for your skin.
I don’t do Botox for any area. My last one was some 15 years ago. I deal with “eleven” (11) wrinkles between my eyebrows by applying meso to that area. It requires only 2 drops, one in each line at a depth of 1 mm (no bleeding). Then, couple hours later, I apply a triangle sticker called “smoothie” to that area for several hours. And the miracle happens - “11” is gone. If your “11” is not very pronounced, wearing just one sticker triangle (smoothie) on that area at night may cure it forever.
I did botox twice some 10 years ago for crows feet, but really did not like the results. It altered my face expression and I almost did not recognize my smile anymore. And yes I did not have crows feet, but other muscled compensated and had this really strange wrinkles below my cheeks.
Forehead and brow area is really difficult to inject properly for men, as muscles are relatively stronger and/or your brows can get a slight curve which feminizes the face. I would really not recommend botox.
But if you decide, try to get a really knowledgeable injector that injects lot of men and try “baby” botox first, to see if you like the result. You can always add more.
Some more clarification on what you intend with the “smoothie “ you mention would be so much appreciated 
Smoothie will take a wrinkle away. It flattens it. It’s similar to ironing your shirt. Try it. Before you buy it, try to apply a piece of scotch on your wrinkle and see what happens in an hour.
This is how “smoothie” looks:
And this is the result of it:
Smoothie is the trade mark ? Will definitely try; your pictures are incredible and you look so much younger ! 
You can find all kinds of skin smoothies on Amazon. Different shapes for different areas.
Facial Smoothies LONG Wrinkle Remover Strips, 48 forehead anti wrinkle patches Amazon.com
has anyone ever heard of using nmn topically - i guess not because of its low solubility at only 1.8mg/ml while NR is 58mg/ml or what about just niacin=nicotinic acid is vitamer of vit B3 soluble 18g/L or niacinamide= nicotinamide soluble at 17g/L . Ofcourse solubility is not the only or likely not the most important consideration. So now of these 4 : NR , NMN , niacinamide , or just niacin is the most suitable and in what conditions with what else and which is the cheapest per unit mass. I seem to recall out of these 4 only niacinamide is commonly listed. So where do u get the advantage or whatever of using NR instead ? What if injected at what concentration would they clog or not clog say a 30awg needle.