Dietary restriction impacts health and lifespan of genetically diverse mice

[Neo]

See also

Could Eating Less Help You Live Longer? NYT science synthesis piece

Calorie restriction and intermittent fasting both increase longevity in animals, aging experts say. Here’s what that means for you. Several researchers pointed to a process known as autophagy, where the body eats up malfunctioning parts of cells and uses them for energy. This helps cells function better and lowers the risk of several age-related diseases. In fact, scientists think that one of the main reasons calorie-restricted diets make mice live longer is because the animals don’t get sick as early, if at all, said Dr. Richard Miller, a professor of pathology at the University of Michigan. Rafael de Cabo, a senior investigator at the N.I.A. who helped lead the monkey study there, now thinks that while calorie restriction is important for longevity, the amount of time spent eating — and not eating — every day is just as critical. And that might be the case not only for animals, but also for humans. [IMG_7199] [IMG_7200]

Fasting-mimicking diet clinical trial led to 2.5 years of reduced biological aging, 12.5 years increase I max life expectancy if done for 20 years

[IMG_6863] Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk Nature Comms, * Published: 20 February 2024 Star cast that combines profs like Valter Longo and Morgan Levine…: In mice, periodic cycles of a fasting mimicking diet (FMD) protect normal cells while killing damaged cells including cancer and autoimmune cells, reduce inflammation, promote multi-system regeneration, and extend longevity. Here, we performed secondary and exploratory analysis of blood samples from a randomized clinical trial (NCT02158897) and show that ***3 FMD cycles in adult study participants are associated with reduced insulin resistance and other pre-diabetes markers, lower hepatic fat (as determined by magnetic resonance imaging) and increased lymphoid to myeloid ratio: an indicator of immune system age. Based on a validated measure of biological age predictive of morbidity and mortality, 3 FMD cycles were associated with a decrease of 2.…

Fasting-mimicking diet clinical trial led to 2.5 years of reduced biological aging, 12.5 years increase I max life expectancy if done for 20 years

Published: 01 March 2024 Systemic proteome adaptions to 7-day complete caloric restriction in humans Nature Metabolism We demonstrate nine distinct proteomic response profiles, with systemic changes evident only after 3 days of complete calorie restriction based on in-depth characterization of the temporal trajectories of ~3,000 plasma proteins measured before, daily during, and after fasting. The multi-organ response to complete caloric restriction shows distinct effects of fasting duration and weight loss and is remarkably conserved across volunteers with >1,000 significantly responding proteins. The fasting signature is strongly enriched for extracellular matrix proteins from various body sites, demonstrating profound non-metabolic adaptions, including extreme changes in the brain-specific extracellular matrix protein tenascin-R. Using proteogenomic approaches, we estimate the health consequences for 212 proteins that change during fasting across ~500 outcomes and identified p…