Dietary Restriction and Rapamycin Affect Brain Aging in Mice by Attenuating Age-Related DNA Methylation Changes

Another paper released this month that looks at Dietary Restriction (or Caloric Restriction /CR) and rapamycin.

The fact that dietary restriction (DR) and long-term rapamycin treatment (RALL) can ameliorate the aging process has been reported by many researchers…

Through functional enrichment analysis of genes in which DNA methylation or gene expression can be affected by DR/RALL, we found that DR/RALL may retard aging through a relationship in which DNA methylation and gene expression work together not only in the same gene but also in the same biological process. This study is instructive for understanding the maintenance of DNA methylation by DR/RALL in the aging process, as well as the role of DR and RALL in the amelioration of aging.

Full Paper Here: Dietary Restriction and Rapamycin Affect Brain Aging in Mice by Attenuating Age-Related DNA Methylation Changes

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Yet another study illustrating that DR and Rapamycin elicit both different and beneficial pathways to longevity. Rapamycin should not be viewed as an absolute/universal DR mimetic.

So do them both, stack as many interventions as possible together! There is no do over.

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