DHA supplementation decreases the brain uptake of DHA and AA?

#21

I don’t use DHA. I’ll change my mind when good data in favor of it appears (RCT, MR, or longitudinal study adjusted for supplementation, fish consumption, exercise and income).

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#22

For clarity, I’m in no way saying she is correct, but I’m simply sharing what just arrived in my inbox from gethealthspan.com

I think you’ve mentioned her before, so this is probably not new to you

Also @CronosTempi

#23

The link you shared says “EMAIL_CAMPAIGN_2023_08_10_04_00” so it seems to be an old campaign. We’ve already discussed this article. Rhonda Patrick is a bullshiter and what she says is wrong, neither lysophosphatidylcholine-bound omega-3 fatty acids nor krill oil increase brain DHA in APOE4 mice (and she never answered my emails and tweets about these papers): Predicting Alzheimers & Dementia (and minimizing risk) - #554 by adssx

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#24

Also in supplements the DHA can oxidise faster potentially compared to EPA in regular ethyl ester form. The EPA only versions are too expensive for most to run long term at a good enough dose. Though it doesnt seem that the EPA+DHA combinations (as long as EPA>DHA in them) will have as negative effect as DHA only

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#25

I wouldn’t take RP’s advice for a variety of reasons. That said, I have a slightly different view than Antoine. The fact is, we don’t have data on supplementing a modest amount of DHA in a pulsatile way, like once a week (similar to fish eating). After all, it’s the dose that makes the poison, and hormesis is a perfect example. What if the same is true for DHA? Now, I never supplemented with DHA. But if I were an ApoE4 with family history, I would supplement with EPA and I would take a once weekly small additional DHA dose. This would be based on risk/reward odds distribution of possible harm vs covering options. It’s insurance against being wrong, essentially game theory, built in fault tolerance.

EDIT: I have glanced over that RP text, but there’s a lot of nuance to discuss, and I can’t do it right now. However, there are several assumptions built in I disagree with.

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