Development of CMLase - an enzyme engineered through the directed evolution of over 500 million variants to specifically oxidize CML and restore the native lysine residue

#1

https://www.nature.com/articles/s41467-026-75141-2

This would easily have been a SENS-project

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New enzyme engineered to break and clean-up AGEs
#2

This is the best scientific break through I’ve read in a long time.

edit: but after a quick look and read,
image

regarding reaction byproducts, hydrogen peroxide and glyoxylate are naturally present in biofluids and efficiently cleared by metabolic enzymes.

This scenario seens dangerous to me. It isn’t really a small amount in the active tissue, where now multitude of pinpoint reactions result in the focally concentrated amounts of hydrogen peroxide and glyoxylic acid in the tissue, resulting in a wave of oxidative damage…

just saying.

#3

This is amazing.

Oxidative damage can be mitigated. Combine with high dose NAC or injectable glutathione, or something like this.

#4

I know it can be (somewhat), but think about electrolysis for hair removal, which produces H2O2 in a specific location; zap and the hair follicle is dead. See what I mean? ANyhow, I’m sure to hear more about this (or maybe never again…), it’s not like I have access to it and willing to inject it any time soon.

#5

This hasn’t even been tested in animals yet. This is genuinely a completely new form of this enzyme. Very exciting!

2 Likes
#6

Super exciting stuff, this really is the best time to be alive.

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#7
1 Like