Development of CMLase - an enzyme engineered through the directed evolution of over 500 million variants to specifically oxidize CML and restore the native lysine residue

#1

https://www.nature.com/articles/s41467-026-75141-2

This would easily have been a SENS-project

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#2

This is the best scientific break through I’ve read in a long time.

edit: but after a quick look and read,
image

regarding reaction byproducts, hydrogen peroxide and glyoxylate are naturally present in biofluids and efficiently cleared by metabolic enzymes.

This scenario seens dangerous to me. It isn’t really a small amount in the active tissue, where now multitude of pinpoint reactions result in the focally concentrated amounts of hydrogen peroxide and glyoxylic acid in the tissue, resulting in a wave of oxidative damage…

just saying.