This topic is of interest to me, as I’ve had to have ACDF surgery recently as a result of cervical disc disease. Interestingly, mTOR is involved, among other things. The condition is genetically driven, so not much I could have done about it. But I have been looking at bisphosphonates for years now, and this is an interesting angle. Now, this is in zebrafish, but if it applies in humans, it could be an important development.
Targeted modulation of phosphate and lipid metabolism reduces ligament mineralization in col9a1bdeficient zebrafish
https://www.nature.com/articles/s42003-026-10702-1
Article:
A drug already used for osteoporosis blocked spinal damage in a new study