Decoding stem cell rejuvenation factors (Translating Aging Podcast)

RapAdmin · November 28, 2024, 5:44am

Listen at this link:

Markus Gstöttner is the CEO of Clock.bio, a company devoted to extending and improving the quality of life by reversing the harmful effects of time in our cells. In this episode, Gstöttner shares how his company is working to extend healthspan by understanding and harnessing the natural rejuvenation capabilities of stem cells. The conversation explores Clock.bio’s groundbreaking approach to identifying the genes and pathways involved in cellular rejuvenation, and their vision for translating these discoveries into therapies.

The Finer Details:

How induced pluripotent stem cells (iPSCs) naturally resist and reverse aging
Clock.bio’s novel platform for forcing stem cells to age and studying their spontaneous rejuvenation
The company’s comprehensive genetic screen identifying over 150 rejuvenation-related genes, the Atlas of Rejuvenation Factors
Strategies for validating these discoveries and developing therapeutic applications
The path from discovery to clinical t

https://clock.bio/

RapAdmin · November 30, 2024, 2:58am

What’s the secret to living to 100? Centenarian stem cells could offer clues

A bank of cells from people more than 100 years old gives scientists

Scientists in Boston, Massachusetts have made reprogrammed stem cells from the blood of centenarians. They plan to share the cells with other researchers to better understand the factors that contribute to a long and healthy life. Early experiments are already providing insights on brain ageing.

https://www.nature.com/articles/d41586-024-03886-1