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I think he was scaremongering about GLP-1s. I am myself not a major fan of GLP-1s etc, but although there are issues about side effects, the absolute risk is really low and it was presented more as a conspiracy theory than as a scientific issue.
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I listened to the podcast and it was amazing “how little” David Sinclair actually shared, given that it was a 2+ hour conversation. He felt more like a salesman than a scientist at times and that his excitement (or perhaps delusion) is ahead of where the research actually lands. Having said that, I do hope that his trials on OSK are successful, though I take most anything he says with a grain of salt.
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He is good at Public Relations, but there is a tension between PR and accuracy.
I don’t think the idea that there is a backup copy of the epigenome holds water.
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