What does this mean? Trial starts a year from now?
1 Like
the eye is linked to the brain, they are both neuronal in nature and dont divide aka post mitotic.
from what i gather, david also seems to be having good results in brains.
and liver.
i think wherever osk can be delivered via aavs, they can work if the delivery is good enough.
its really a delivery issue. also aavs seem to modify the dna and isn’t exactly like drinking coffee.
disclaimer: no biology background but been reading on these for a decade.
typo.
it has started as of dec 2025.
so we should see preliminary results soon, in 2026 hopefully.
they will probably do the liver trials soon as well.
a lot of older rich people or people who have some illnesses will be willing to try this i guess if the trials work.
but i recall it was mentioned it currently costs like 5 million to do this currently so it aint exactly cheap…
realistically, it will be 2030. but the world will await the results keenly i guess.
phase 1 = safety only but they should be able to report some results
phase 2 = efficacy?
the next 5-10y are very interesting, i think if we can stick around for 10 more years, we really have a good chance we can be doing osk, sb000, or whatever mrna stuff and reaping the results of current trials
1 Like
Yeah. I’ve noticed…
2 Likes
Thanks for the clarification.
The strategy you outlined seems sensible. I believe it will be a long time before any treatment is approved…the FDA will set high hurdles.
The biggest problem I see is not actually the treatment itself as the delivery vehicle they’re going with. Viral vectors have been getting some bad press lately.
@rapaalv , I recommend you review this thread that covers some of the reasons that many people are disappointed with David Sinclair. While I am sure he and his team have done some good work, there is a history of excessive hype in his proclamations… Matt Kaeberlein resigns from Academy for Health and Lifespan Research, calls David Sinclair a snake oil salesman
1 Like
Hype brings eyeballs and more importantly depending on what for, makes people learn that certain things are possible… like that there are a category which are “longevity molecules”, Sinclair contributed a lot recently with NMN I believe, for example, and it was also an interesting thing.
Before you create mindshare of a concept of longevity molecule, not much else is possible.
If you don’t think he did this with NMN see the tens of millions of views on YouTube…
Basically you’re opening up a box in people’s mind regardless what it was initially filled with (NMN), for example.
I didn’t know room temperature superconductors were a thing before the LK-99 hype, and I’m glad to hear about that concept, as are those who are working on them. Mindshare is important, if not the most important thing!
Of course it’s probably not possible to do this with this goal in mind, it’s more of a side effect I suppose.
Matt Kaeberlein rarely misses a chance to take a thinly veiled shot at Sinclair every time I hear him speak. I personally think the biggest problem with the Sinclair debacle is that Sinclair and his other small group of investors walked away with $720 million. Jealousy? Give it up Matt.
I like Matt, I like what his new Optispan company is doing with Rapamycin research with companion dogs (results should be published soon), and his Ora Biomedical that uses an automated robotic system called the WormBot to conduct high-throughput lifespan experiments in C. elegans (roundworms). The platform allows them to test interventions at unprecedented scale, approximately 1,000 molecules per month with proper statistical replication, generating what is likely the largest quality database of longevity interventions ever assembled. The company’s core philosophy challenges the field’s narrow focus on well-known pathways and molecules, arguing that vast areas of chemical and combinatorial space remain unexplored. You can even suggest a molecule that you think has some promise and they’ll test it. The claim is they’ve found some molecules that are ‘better’ than Rapamycin. If you haven’t seen his discussion with the guy who runs that lab next door, here’s it is:
2 Likes
Seems to me that Dr Sinclair has done more for the fields of healthspan and longevity than almost anyone - can someone provide a credible list of 5 people who have done more?
1 Like
Irina Conboy
Hazel Szeto
Mikhael Blagoskonny
Lenny Guarente
Amy Wagers
Matt Kaeberlein
Vladimir Skulachev
Steve Horvath
Aubrey DeGrey
Michael Diamandis
That’s 10 just off the top of my head without resorting to papers or the internet. Sinclair? Pffft!
7 Likes
Probably not with debating this. The question was not about who we like or agree with, it was about impact/how much done for the field.
In my reading of things, few on that list come close to Sinclair impact - science wise, awareness for the field, etc.
Anyway, thanks for helping me see how radically different people can see things.
1 Like
Hopefully this is not yet another snake oil product from Sinclair. Trust and respect are hard to build, and so easy to squander away.
1 Like
Suren Sehgal put a lot of effort into Rapamycin back at the stage where it’s pretty much thankless. He persevered and believed. Never sold snake oil to anybody.
I don’t hate Sinclair but what he did with resveratrol was pretty dodgy. Hopefully he uses that $720 million for the good of longevity is all I can say.
Do you mean Peter?
Personally i dont have expertise in biology so i cannot judge sinclairs work
I am his fan
U are entitled to ur opinions
I do have a baxkgrouns in the social sciences and have read biology papers leisurely for years
David is a professor his job is ti amplify his labs work and get funding of course
Osk seems to be very interesting to me
2 Likes
Science is hard
Reversing aging is obv goihg ti be filled with ups and downs
But i think we are really there now
At least in mouse and primates haha
Not just david lab but other labs
1 Like
We really aren’t. Nobody has mice living much longer, even the crooks can’t do it. I had high hopes for the people in Brazil trying to redo Harold Katcher’s E5. They couldn’t find rats the right age and are still waiting I think till June?
1 Like
Huh?
Osk has worked v well for mice in organs and also lifespan extension.
Ryan lu has a paper on extending mice lifespan with osk here. They basically injected very old mice with osk and did 1 week on 1 week off.
Those injected lived significantly longer (100%). Its a delivery issue, they cant get osk to every aged cell probably.
If they injected osk into middle aged mice, i guess the extension will be more in absolute terms but they cant wait for years for these mice to die so they probably chose 124 week old mice as a proof of concept of lifespan extension.
I am pretty sure these results are reproducible so we shall see if labs worldwide are able to reproduce and improve on the genes and delivery.
Itp has tested substances such as rapa asta etc that extended median lifespan of mice
I think if they can regrow cut optic nerves they probably can extend median lifespan … esp with heart diseases and cancer also progressing in treatments
Rapa has a lot of side effects i heard. David tried it but stopped. The bryan johson guy too he stopped.
Ok, yes it looks like it makes them live maybe on average 5 weeks more. Still that’s average, treated mice are dying right along. The curve goes down to zero. I look forward to future reports on this one. Interesting that it works at all.
The mice aren’t living forever yet.