The other day on twitter:
I wonder if heâs being vague on purpose? He says âI haveâ but that could be interpreted as âI have in the pastâ since the normal non-vague response would be âI doâ
Iâm sure heâs tried it. ⌠who knows for how long, or if heâs pulse dosing and doesnât want to talk too much about itâŚ
2 Likes
Found this quite recent youtube-clip where David Sinclair tells that he has tried rapamycin once
âI did try it once. I caught a cold for the first time in years and so you know Iâm little bit warried about it. But I think the science behind it is really strong.â
Source: Rapamycin | Dr David Sinclair Interview Clips - YouTube
Curious question, is getting a cold a common side effect of rapamycin?
1 Like
Why are you guys mentioning and paying attention to this charlatan?
Anything that this guy sais should be treated as a joke.
What do you take most offense with Sinclair?
Sinclair is promoting longevity - Thatâs a plus.
Sinclair is pushing Resveratrol - Thatâs a minus.
Sinclair is pushing NMN - Thatâs inconclusive.
Sinclair has brought attention to aging as a disease - Thatâs a plus.
Sinclair truly wants to help people live longer - Thatâs my belief.
5 Likes
I wouldnât have known about rapa if it were not for Sinclairâs book, so for me heâs a plus.
4 Likes
David Sinclair did include a good section in his book on rapamycin, Iâll definitely give him that:
âIt is for this reason that if you were to make a pilgrimage to Rapa Nui, you might come upon a small plaque at the site where S. hygroscopicus was discovered. âAt this site,â the plaque reads in Portuguese, âsoil samples were obtained in January 1965 that allowed the production of rapamycin, a substance that inaugurated a new era for patients who need organ transplants.â
I suspect that a larger plaque may soon be in order, because the discovery of S. hygroscopicus set into motion a tremendous amount of research, much of which is still ongoing and some of which has the potential to prolong vitality for countless other people. Because in recent years it has become clear that rapamycin isnât just an antifungal compound and it isnât just an immune system suppressor; itâs also one of the most consistently successful compounds for extending life.â
âWant to know what the worldâs most prominent arbiters of great science think about the potential of TOR and the molecules that inhibit it [e.g. rapamycin] to change the world? The three men who discovered TOR in yeast, Joseph Heitman, Michael Hall, and Rao Movva, are on a lot of peopleâs shortlists for the Nobel Prize in Medicine or Physiology. My colleague across the river at MIT, David Sabatini, who identified mTOR, was named a Clarivate Citation Laureate for having his work cited most frequently in top-tier peer-reviewed journals; the Clarivate list has predicted more than forty Nobel Prize winners since 2002.â
Excerpt From
Lifespan
David A. Sinclair
3 Likes
except that he was pushing hard for everything else but rapamycin in all his talks, even with this interview, he is almost forced to admit.
1 Like
True⌠but its natural for a scientist to focus on his own work⌠thats what pays the bills and is his primary focus.
and - heâs been very open and positive generally about rapamycin: David Sinclair on Rapamycin
Iâm just thankful that heâs finally talking about his rapamycin use. This is a big win for the rapamycin community. The higher visibility it gives rapamycin helps it become more mainstream and hopefully that will result in more clinical studies being done, and more resources going into mTOR inhibitors.
The newly released Peter Diamandis video, at the point where David Sinclair says heâs taking rapamycin (âon and offâ)
4 Likes
Of course it was a âCertified Reiki Masterâ that turned David Sinclair towards veganism.
Hereâs Serenaâs website https://serenaloves.com/
There is for sale there âhealing crystalsâ, âSelf-Love Jewelryâ.
Is this Davidâs softer side weâre seeing?
I appreciate that he just goes for it. Full steam ahead. My nutritionist is a certified Reiki Master, not many can say so!
Ultimate Havard Scientist with Massive Lab + Reiki Master Nutrition.
Perfectly balanced.
Their joint venture:
They have a youtube channel here:
The person who has seen most of their videos is probably⌠Dr. Brenner.
3 Likes
I always thought David Sinclair has an ideal marriage, but just found out last night (if it is true) that he divorced his wife of 23 yr and hooked up with Poon who is a political sci major and now a âlongevity expertâ per Sinclair! And if this is true, I am hugely surprised that this is literally not written up anywhere on the internet. I am not judging him on the divorce part, just surprised. https://www.boston.com/real-estate/real-estate-news/2016/07/29/how-a-small-newton-backyard-became-a-childrens-delight-of-wildlife-and-plantings/
1 Like
I guess itâs more difficult for a renowned person to be a paradigm of virtue. Have you read about the former girlfriend of Bryan Johnsonâs lawsuit? What a mess.
Their lives donât bear up to scrutiny. And they want to extend them, to spread even more misery around than they already do.
1 Like
My only point is that for a high-profile person like that, his divorce last yr and his relationship with his new business partner Poon (longevity expert) are not mentioned at all ANYWHERE, considering when Brady split with Gisele, the internet just went wild and mostly blamed it on Brady.
1 Like
Maybe it is, maybe it isnât⌠but we have to remember that people are people and people are messy. We have this idea that achieving great things in one area of life means you are equally great in every single area of life.
We are rolling disasters and to be honest, itâs amazing any of us ever get anything done. This is why the sceintific method was such an advancement in the world because it was a way to insulate science from the full brunt of human fallibility.
With the internet, we know so much more about the details of famous peopleâs lives. But weâre still kind of living in the old world, where we elevate some people as demigods and then act surprised when it turns out theyâre just as messed up as we are.
Weâre all messes, in one way or another. Maybe longevity will give us all enough time to learn and evolve into something a little better 
4 Likes
I was happily married for 53 years.
One of the problems of working in some environments is working with attractive members of the opposite sex. In my work environment, I was spending much more time with co-workers than I was spending with my wife. I have traveled with and worked with attractive women in remote locations. So, I understand the temptations of âoffice romanceâ because, basically you are spending more time with them than your spouse. And, in addition, you may share more common interests with them than your spouse.
3 Likes
Only semi-related topic, I do wonder what sort of societal effects a sudden longevity discovery would have. Letâs say, rather than a gradual increase in lifespan, a dramatic discovery was announced that meant most people alive today would live an extra 50 or 100 years.
The next week would see the largest number of divorces and job resignations in recorded history.
Many people are very happy in their current situations. But another very common state, unfortunately, is people who are unhappy but feel that itâs âtoo lateâ to change or start over. Theyâre just grinding out the years in their current situation because they see life being âmostly overâ.
But the prospect of another 50 or 100 years in that situation would light a fire under them. Youâd see people going through a âreverse midlife crisisâ. Doors opening that they thought had been closed. Youâd have a period of relative chaos, with all the calculations people had made about their lives suddenly being turned upside down with the prospect of a longer life.
6 Likes
Iâm not too interested in the personal lives of longevity researchers (any more than Brady / Gisele) but there is some writing suggesting heâs gotten remarried to Poon at some point in the past few years:
Dieting is the secret to antiaging, according to Sinclair, writer of Lifespan: Why We Age and Why We Donât Have To. He consumes up to two cups of his wife Serena Poonâs green tea matcha, which contains anti-inflammatory and cancer-preventive chemicals.
Source: The four routines of a lifespan expert have made him appear a decade younger - Go 4 Healthy Life
I feel bad for the family - must have been a lot of stress for the children.
3 Likes