Dr Green is an early adopter family doctor pushing the “longevity” hype, off label envelope. Dr B is a world class cancer researcher, and thus, I would imagine, more grounded in the fundamental science. I’ve read many of his papers and listened to several interviews, he just seems more convincing to this layperson.
I try to keep an open mind, but this one I think is still early days (for me), would like to see more efficacy/safety, hasn’t tipped the scale yet.
Fisetin only in a liposomal form.
IMO most of the hype comes from the various of opinion papers and summary/review articles Dr. Blago has published over the years. I pay attention to what both of them are saying/doing while trying to remind myself this is all experimental. It is interesting that their opinions diverge with senolytics and I wonder if Dr B would change his mind in the face of accumulating evidence.
Although senolytics like Dasatinib and Fisetin seem to act as a type of geroprotector, the part in question and doubtful is that are they true age-slowers. The mechanism of senolytics suggest its a geroprotector with minimal true age-slowing characteristic. A compound like this extends average lifespan when administered in old age but does not have much cumulative effect when started much earlier. However Im sure low doses of senolytic like compounds no matter the age are beneficial.
In comparison CR or Rapa by their mechanism suggest they are true age-slowers.
Thinking about trying Dasatinib and fisetin and/or quercetin. Any thoughts or experience on timing it with rapamycin? Would taking them at the same time be synergistic or would it be better to take them on a rapamycin trough or break? 54 yo male.
The combination is synergistic against some types of cancer, but I haven’t seen any results about senolytic activity (which will vary across cell types).
My instinct would be to separate for safety, but you could try to find results from this clinical trial to better judge the combined safety and dosage issues.
At the present time, with insufficient data, I am concerned about killing or clearing out cells, when its uncertain if that’s an important thing to do for longevity. I am glad there are people who will try on themselves first.
Dasatinib is a very potent drug with numerous side effects…I was single dosing it for a few years on a quarterly basis, and even with taking Ondansetron proactively, I still DREADED that single dose (experimented with up to 150mg)…nausea aside and albeit short acting, the side effects are absolutely brutal.
After looking at Aubrey DeGrey’s Mouse experiment, where he used a senolytic (Not D+Q) the results were that senolytics had no effect on lifespan. The Mayo Clinic has also failed to show positive results from senolytics as well (Fisetin). I have tried both Fisetin and Quercetin, and other than really bad diarrhea, I can’t really tell a difference or see anything in my blood work.
For me, I’m passing on senolytics. It sounds great in theory, but show me the human data.
Interesting. What dose of D were you taking? I have taken 100mg ( I weigh 112lb) and I have never had any sides. My husband takes 150mg, no sides. I did the 3 consecutive day course. Now I wonder if I got one of those “bad batch” chemo drugs that India is being accused of producing.
Headache, fatigue (slept almost all day one time), muscle stiffness (especially in the neck), swelling (hands get very bad), but the worst side effect was nausea and vomiting…a single concurrent dose of ondasetron mitigated the vomiting, but still had some moderate nausea. I was doing 100mg most doses with 2,000mg of quercetin, but tried 150mg on several occasions. The drug profoundly affects so many systems of the body, I would indeed question the authenticity of the product if I got zero side effects from it. By far the most hardcore side effects I’ve ever experienced from any substance.
What dose of ondansetron were you taking with it? I wonder if a higher dose and maybe some high potency ginger would have further helped. Do you feel like the quarterly regimen helped?
Ondansetron dose was just 4mg…I contemplated going to 8mg but the the nausea was still very manageable on 4mg…the vomiting from Dasatinib was like nothing I had ever experienced…painful dry heaving for like 20 minutes on end…the kind you don’t wish upon your worst enemy. lol Tough to say I can isolate what effects the quarterly dosing was having because I’ve been on rapamycin the whole time, but in the days following a dose, I did anecdotally (and maybe placebo, who knows) feel a burst of vitality, with higher energy, no aches/pains, more restful sleep, etc. The evidence that D+Q combo reduces senescent cell burden in humans is mounting, to include biopsies of certain tissues. Whether it translates into any lifespan increase is still yet to be determined however.
Where do you source Dasatinib? I have mine from Dr. Green but once I run out, am I going to find another source?
cronoslogical, The Dasatinib has never given me a problem either, but the Quercetin does cause some problems which are manageable. I never do D + Q and Rapamycin together. I drop the Rapamycin when doing the D + Q protocol.
I get mine from an Indian source.
Most of the regular indian vendors we have on our list sell dasatinib.
Sorry, couldn’t resist. This is one of the longer lists I have seen from the Mayo Clinic.
I tried to take it but couldn’t overcome the side effects, mainly diarrhea. This is not a common side effect of taking dasatinib. I would suggest reading the Mayo Clinic article before proceeding with your polypharma venture. This may be one of those interventions where the risk-reward ratio is unfavorable.
The common side effects are:
More common
Bleeding gums
bloody or black, tarry stools
body aches or pain
burning, tingling, numbness, or pain in the hands, arms, feet, or legs
chest pain or tightness
chills
constipation
cough
coughing up blood
decrease in the amount of urine
dizziness
ear congestion
fainting
fast, slow, or irregular heartbeat
fever
full or bloated feeling
headache
hoarseness
increased menstrual flow or vaginal bleeding
loss of voice
lower back or side pain
noisy or rattling breathing
nosebleeds
painful or difficult urination
pale skin
paralysis
pressure in the stomach
prolonged bleeding from cuts
red or dark brown urine
runny or stuffy nose
sensation of pins and needles
severe stomach pain
sneezing
sore throat
stabbing pain
swelling of the stomach area
swelling of the face, fingers, hands, feet, or lower legs
trouble breathing
ulcers, sores, or white spots in the mouth
unsteadiness or awkwardness
unusual bleeding or bruising
unusual tiredness or weakness
vomiting of blood or material that looks like coffee grounds
weakness in the arms, hands, legs, or feet
weight gain
Less common
Blue lips and fingernails
chest discomfort
coughing that sometimes produces a pink frothy sputum
difficult or fast breathing
dilated neck veins
increased sweating
irregular breathing
loss of appetite
nausea
stomach pain, severe
swelling in the legs and ankles
vomiting
yellow eyes or skin
The end. 
A two-drug combination frequently used in anti-aging research causes brain damage in mice, report University of Connecticut researchers in the Proceedings of the National Academy of Sciences. The findings, titled “Senolytic treatment induces oligodendrocyte dysfunction and demyelination in the corpus callosum,” should make doctors cautious about prescribing the drug combo prophylactically, but also suggest new ways to understand multiple sclerosis.
“When you administer this cocktail to an animal, young or old, the myelin is damaged, which makes it disappear. Even worse in the young animals” than in the aged ones, says UConn School of Medicine immunologist Stephen Crocker.
Myelin is the insulation around the nerves. When it disappears, nerves don’t work as well, and people can develop numbness, pain, and lose the ability to walk. They can also have problems thinking and remembering. Missing myelin is the primary cause of multiple sclerosis. Crocker and his colleagues saw it happen to mice when treated with dasatinib+quercetin (D+Q) at doses often used to treat aging-related inflammation and metabolic disorders.
Popular anti-aging combo under scrutiny
D+Q is a popular combination of medicines in anti-aging research. Many studies have shown it works to eliminate aged cells that contribute to inflammation and other age-related symptoms. It is being tested for a range of diseases, from type II diabetes to Alzheimer’s. People in the anti-aging scene sometimes even use it off-label, though the medical community discourages this. Very few studies have looked at its effect on the brain.
Full writeup: https://medicalxpress.com/news/2026-03-anti-aging-therapy-worsen-myelin.html
Senolytic treatment induces oligodendrocyte dysfunction and demyelination in the corpus callosum, Proceedings of the National Academy of Sciences (2026). DOI: 10.1073/pnas.2524897123
Well that’s scary. I wonder if the doses they used were relevant to doses used by humans? The full paper is paywalled.