Dr Green is an early adopter family doctor pushing the “longevity” hype, off label envelope. Dr B is a world class cancer researcher, and thus, I would imagine, more grounded in the fundamental science. I’ve read many of his papers and listened to several interviews, he just seems more convincing to this layperson.
I try to keep an open mind, but this one I think is still early days (for me), would like to see more efficacy/safety, hasn’t tipped the scale yet.
IMO most of the hype comes from the various of opinion papers and summary/review articles Dr. Blago has published over the years. I pay attention to what both of them are saying/doing while trying to remind myself this is all experimental. It is interesting that their opinions diverge with senolytics and I wonder if Dr B would change his mind in the face of accumulating evidence.
Although senolytics like Dasatinib and Fisetin seem to act as a type of geroprotector, the part in question and doubtful is that are they true age-slowers. The mechanism of senolytics suggest its a geroprotector with minimal true age-slowing characteristic. A compound like this extends average lifespan when administered in old age but does not have much cumulative effect when started much earlier. However Im sure low doses of senolytic like compounds no matter the age are beneficial.
In comparison CR or Rapa by their mechanism suggest they are true age-slowers.